TLDR Trichostatin A helps restore hair-growing ability in skin cells used for hair regeneration.
The study from 2019 found that Trichostatin A (TSA), a histone deacetylase inhibitor, can restore the hair follicle-inductive capacity of skin-derived precursors (SKPs) that diminishes during ex vivo culture expansion. TSA treatment was shown to alleviate SKP senescence, increase alkaline phosphatase activity, and enhance hair genesis when SKPs were transplanted into mice. This effect was linked to increased acetylation of histone H3 and elevated expression of bone morphogenetic proteins (BMPs), suggesting the BMP pathway's involvement in hair follicle regeneration. The study, which involved implanting TSA-treated SKPs into mice, indicated that TSA could be a potential therapeutic agent for hair follicle regeneration and bioengineering. The number of mice used in the hair genesis experiment was 5, and there were 3 technical replicates for the RT-PCR experiment.
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17 citations
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September 2016 in “Stem cells translational medicine” Using bioreactors, scientists can grow more skin stem cells that keep their ability to regenerate skin and hair.
44 citations
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July 2016 in “Stem Cells Translational Medicine” Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.
256 citations
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October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Growing human skin cells in a 3D environment can stimulate new hair growth.
28 citations
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October 2013 in “Journal of Investigative Dermatology” The document concludes that dermal papilla cells are key for hair growth and could be used in new hair loss treatments.
60 citations
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January 2012 in “Stem Cells and Development” Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.
330 citations
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December 2009 in “Cell stem cell” SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.
63 citations
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September 2009 in “Regenerative Medicine” Scientists found a way to grow human hair cells in a lab that can create new hair when transplanted.
