TLDR Trichostatin A helps restore hair-growing ability in skin cells used for hair regeneration.
The study from 2019 found that Trichostatin A (TSA), a histone deacetylase inhibitor, can restore the hair follicle-inductive capacity of skin-derived precursors (SKPs) that diminishes during ex vivo culture expansion. TSA treatment was shown to alleviate SKP senescence, increase alkaline phosphatase activity, and enhance hair genesis when SKPs were transplanted into mice. This effect was linked to increased acetylation of histone H3 and elevated expression of bone morphogenetic proteins (BMPs), suggesting the BMP pathway's involvement in hair follicle regeneration. The study, which involved implanting TSA-treated SKPs into mice, indicated that TSA could be a potential therapeutic agent for hair follicle regeneration and bioengineering. The number of mice used in the hair genesis experiment was 5, and there were 3 technical replicates for the RT-PCR experiment.
17 citations,
September 2016 in “Stem cells translational medicine” Using bioreactors, scientists can grow more skin stem cells that keep their ability to regenerate skin and hair.
44 citations,
July 2016 in “Stem Cells Translational Medicine” Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.
256 citations,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Growing human skin cells in a 3D environment can stimulate new hair growth.
28 citations,
September 2013 in “Journal of Investigative Dermatology” The document concludes that dermal papilla cells are key for hair growth and could be used in new hair loss treatments.
60 citations,
July 2011 in “Stem Cells and Development” Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.
330 citations,
December 2009 in “Cell stem cell” SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.
63 citations,
September 2009 in “Regenerative Medicine” Scientists found a way to grow human hair cells in a lab that can create new hair when transplanted.
November 2022 in “Regenerative Therapy” Advancements in tissue engineering show promise for hair follicle regeneration to treat hair loss.
42 citations,
February 2021 in “Signal Transduction and Targeted Therapy” Hair follicle regeneration possible, more research needed.
17 citations,
December 2019 in “Stem Cells International” Bioactive molecules show promise for improving skin repair and regeneration by overcoming current challenges with further research.
51 citations,
November 2013 in “Drug Discovery Today” Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.
Chemicals and stem cells combined have advanced regenerative medicine with few safety concerns, focusing on improving techniques and treatment effectiveness.
