Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

    July 2022 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Joon Ho Shim, Ji Hye Park, Gulimila Abudureyimu … Dongyoun Lee
    Studysummary This study revealed that BMP5 in onychofibroblasts may play a key role in the differentiation of nail matrix keratinocytes, highlighting transcriptional similarities between nail and hair structures.
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    Research cited in this study 15

    1. Mapping the Molecular and Structural Specialization of the Skin Basement Membrane for Inter-Tissue Interactions Nature communications · 2021
    2. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020
    3. Mammalian-Specific Ectodermal Enhancers Control the Expression of Hoxc Genes in Developing Nails and Hair Follicles Proceedings of the National Academy of Sciences · 2020
    4. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    5. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    6. STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction Journal of Investigative Dermatology · 2016
    7. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    8. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    9. The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    10. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    11. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    12. Hair and Nail Relationship: A Comparative Study Skinmed · 2005
    13. Expression of Hair Keratins in the Adult Nail Unit: An Immunohistochemical Analysis of Onychogenesis in the Proximal Nail Fold, Matrix, and Nail Bed British Journal of Dermatology · 2004
    14. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    15. Keratin Expression in the Normal Nail Unit: Markers of Regional Differentiation British Journal of Dermatology · 2000

    Related research 4

    1. Expression Patterns of Hair-Related Keratins and Epithelial Keratins in Onychopapilloma: The Significance of Clarifying the Origin of Onychopapilloma Frontiers in Medicine · 2022
    2. Keratins of the Human Hair Follicle International review of cytology · 2005
    3. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    4. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003