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research Mapping of monilethrix to the type II keratin gene cluster at chromosome 12q13 in three new families, including one with variable expressivity

21 citations , September 1997 in “British Journal of Dermatology”

This study found that monilethrix in three unrelated European families is linked to the type II keratin gene cluster on chromosome 12q13, with no evidence of defects in type I keratins.

research Chapter 3 Expression and Modification of Keratins During Terminal Differentiation of Mammalian Epidermis

81 citations , January 1987 in “Current topics in developmental biology/Current Topics in Developmental Biology”

Keratins change and are modified differently in skin layers and body parts.

Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

research Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

10 citations , July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study revealed that BMP5 in onychofibroblasts may play a key role in the differentiation of nail matrix keratinocytes, highlighting transcriptional similarities between nail and hair structures.

research The RAIG Family Member, GPRC5D, Is Associated with Hard-Keratinized Structures

64 citations , March 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study describes GPRC5D's unique expression pattern in tissues that produce hard keratin, with retinoic acid inducing its expression in hair bulb cells and affecting keratin gene regulation.

research Single-cell transcriptomics defines keratinocyte differentiation in avian scutate scales

5 citations , January 2022 in “Scientific reports”

This study identified distinct gene expression programs in keratinocytes responsible for forming hard scales and soft interscale epidermis in chickens, revealing conserved differentiation genes similar to those in human skin.

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learn Alpha Keratin

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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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community Go bald/buzzed, fellas. Your life will improve.

in Chat 227 upvotes 1 year ago

Buzzing or shaving your head can boost confidence and save money on hair loss treatments. Some prefer treatments like finasteride and minoxidil to maintain their hair.

community Oral Minoxidil - Multiple Facial Hair in One Follicle / Pili Multigemini Question

in Minoxidil 117 upvotes 9 months ago

Oral minoxidil can cause multiple facial hairs to grow from one follicle, known as Pili Multigemini, leading to ingrown hairs and zits. Users report increased facial and body hair growth, with some experiencing fewer issues after switching to dutasteride.

community Mature hairlines in general and defining them

13 upvotes 4 years ago

A "mature hairline" is subjective and may not indicate future stability. Finasteride and minoxidil are suggested treatments for hair loss.

community Summary of Procapil video by Haircafe

2 upvotes 1 year ago

Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

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