Ashwagandha-Derived Exosome-Like Nanoparticles Promote Human Hair Growth Ex Vivo
May 2023
Ashwagandha-derived exosome-like nanoparticles Ash-ELN human hair follicles anagen phase hair shaft production RNA sequencing WNT10B RSPO1 VEGFD catagen inducers BMP4 DKK1 TGFB1 anagen/catagen transition hair growth therapies Ashwagandha hair follicles growth phase hair production gene expression hair growth
TLDR Ashwagandha-derived nanoparticles can promote human hair growth.
The study investigated the potential of Ashwagandha-derived exosome-like nanoparticles (Ash-ELN) to promote hair growth using microdissected human hair follicles (HFs) ex vivo. The results showed a significant increase in the number of anagen (growth phase) HFs and hair shaft production after treatment with Ash-ELN. RNA sequencing revealed up-regulation of anagen-promoting mRNAs (WNT10B, RSPO1, VEGFD) and down-regulation of catagen inducers (BMP4, DKK1, TGFB1) in at least 2 out of 3 donors. These findings suggest that Ash-ELN can modulate hair growth by influencing pathways involved in the anagen/catagen transition, indicating their potential as an alternative to human-derived exosomes for hair growth therapies.
