LB1010 Ashwagandha-Derived Exosome-Like Nanoparticles Significantly Promote Human Hair Growth Ex Vivo and In Vivo by Stimulating the Production of the Anagen Promoting Growth Factor VEGF-A

The study investigated the effects of Ashwagandha-derived exosome-like nanoparticles (Ash-ELN) on hair growth. Ex vivo application of Ash-ELN to human hair follicles resulted in increased hair shaft production and a higher number of follicles remaining in the anagen phase. This was associated with increased expression of VEGF-A protein in the dermal papilla and bulb mesenchyme. In a 12-week in vivo study involving 20 patients with pattern hair loss, topical application of Ash-ELN led to an increased anagen-to-telogen hair ratio. Specifically, male subjects with grade II or III hair thinning showed a significant increase in the anagen-to-catagen/telogen ratio. The findings suggest that Ash-ELN promotes hair growth by prolonging the anagen phase, likely through VEGF-A mediated effects on hair follicle angiogenesis and hair cycle regulation.