Ashwagandha Seed Plant Exosome-Like Nanovesicles Promote In Vitro Cellular Regeneration of Human Dermal Hair Follicle, Endothelial and Fibroblast Cells
TLDR Ashwagandha seed nanovesicles may help regenerate hair and skin cells.
The study investigates the regenerative potential of plant exosome-like nanovesicles derived from Ashwagandha seeds (Ash-PELNs) as an alternative to human-derived platelet-rich plasma (PRP) and exosome treatments for hair and skin conditions. In vitro tests showed that Ash-PELNs significantly increased the proliferation of human hair follicle dermal papilla cells (hHFDPCs) by 11.9%, enhanced migration of human endothelial cells (HUVEC) and dermal fibroblasts (hDF) by 82.8% and 67.0% respectively, and promoted HUVEC tubulogenesis by 54.9%. Additionally, Ash-PELNs elevated hDF VEGF-A expression by 39.9% and increased hHFDPC secreted growth factors such as LIF, PLGF-1, FGF-2, and VEGF-A. These findings suggest that Ash-PELNs could be a viable plant-derived topical treatment for hair, scalp, and skin regeneration.
