Ashwagandha Seed Plant Exosome-Like Nanovesicles Promote In Vitro Cellular Regeneration of Human Dermal Hair Follicle, Endothelial and Fibroblast Cells

    July 2022 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    G. Dellacqua, R. Scotland
    Image of study
    TLDR Ashwagandha seed nanovesicles may help regenerate hair and skin cells.
    The study investigates the regenerative potential of plant exosome-like nanovesicles derived from Ashwagandha seeds (Ash-PELNs) as an alternative to human-derived platelet-rich plasma (PRP) and exosome treatments for hair and skin conditions. In vitro tests showed that Ash-PELNs significantly increased the proliferation of human hair follicle dermal papilla cells (hHFDPCs) by 11.9%, enhanced migration of human endothelial cells (HUVEC) and dermal fibroblasts (hDF) by 82.8% and 67.0% respectively, and promoted HUVEC tubulogenesis by 54.9%. Additionally, Ash-PELNs elevated hDF VEGF-A expression by 39.9% and increased hHFDPC secreted growth factors such as LIF, PLGF-1, FGF-2, and VEGF-A. These findings suggest that Ash-PELNs could be a viable plant-derived topical treatment for hair, scalp, and skin regeneration.
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