Ashwagandha Seed Plant Exosome-Like Nanovesicles Promote In Vitro Cellular Regeneration of Human Dermal Hair Follicle, Endothelial and Fibroblast Cells

    July 2022 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    G. Dellacqua, R. Scotland
    Image of study
    TLDR Ashwagandha seed nanovesicles may help regenerate hair and skin cells.
    The study investigates the regenerative potential of plant exosome-like nanovesicles derived from Ashwagandha seeds (Ash-PELNs) as an alternative to human-derived platelet-rich plasma (PRP) and exosome treatments for hair and skin conditions. In vitro tests showed that Ash-PELNs significantly increased the proliferation of human hair follicle dermal papilla cells (hHFDPCs) by 11.9%, enhanced migration of human endothelial cells (HUVEC) and dermal fibroblasts (hDF) by 82.8% and 67.0% respectively, and promoted HUVEC tubulogenesis by 54.9%. Additionally, Ash-PELNs elevated hDF VEGF-A expression by 39.9% and increased hHFDPC secreted growth factors such as LIF, PLGF-1, FGF-2, and VEGF-A. These findings suggest that Ash-PELNs could be a viable plant-derived topical treatment for hair, scalp, and skin regeneration.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 120 results

      community ashwagandha while taking finasteride

      in Finasteride/Dutasteride  6 upvotes 3 months ago
      The user is considering taking ashwagandha while on finasteride to manage side effects, noting it reduces stress but may cause hair thinning. They are unsure if the thinning is due to ashwagandha or normal shedding from finasteride.

      community Taking ashwagandha with finasteride

      in Chat  7 upvotes 1 year ago
      Ashwagandha is used to reduce stress and improve sleep, while finasteride is taken for hair loss. Users report positive effects from ashwagandha and mixed results from finasteride, with some experiencing a slight dip in libido.

      community Ashwagandha Topical Formulation - A 2023 Study

      in Research/Science  10 upvotes 1 year ago
      Ashwagandha topical formulation may increase hair density and reduce hair loss, but results seem too good to be true due to a small sample size. Users are skeptical about its effectiveness and are experimenting with different application methods.

      community Ashwagandha And Hair Loss - Correlation?

      in Finasteride/Dutasteride  6 upvotes 3 years ago
      The conversation discusses whether ashwagandha affects hair loss, with one user noting no increase in hair loss while using it and another suggesting it may help slow hair loss by reducing stress. The original poster is using finasteride daily and is concerned about ashwagandha's impact on hair loss.

      community Can ashwagandha cause hair loss?

      in Finasteride/Dutasteride  13 upvotes 4 years ago
      Ashwagandha is generally considered safe for hair while on Dutasteride, as its effects on testosterone are minimal and it may reduce anxiety. Some users report positive effects on hair thickness and anxiety reduction when using ashwagandha alongside finasteride.

    Related Research

    1 / 1 results