Ashwagandha-Derived Exosome-Like Nanoparticles Promote Human Hair Growth Ex Vivo

April 2023 in “ Journal of Investigative Dermatology ”

A. Le Riche, J. Nienhaus, M. Sousa, R. Scotland, M. Bertolini, G. Dell' Acqua, J. Edelkamp

Ashwagandha exosome-like nanoparticles Ash-ELN hair follicles anagen catagen WNT10B RSPO1 VEGFD BMP4 DKK1 TGFB1 growth phase transition phase

TLDR Ashwagandha nanoparticles help increase hair growth.

The study investigated the potential of Ashwagandha seed derived exosome-like nanoparticles (Ash-ELN) in promoting hair growth. The Ash-ELN were applied to microdissected human hair follicles (HFs) from both male and female donors ex vivo. The results showed a significant increase in the number of anagen (active growth phase) HFs and hair shaft production. RNAseq analysis revealed an up-regulation of anagen promoting mRNAs (WNT10B, RSPO1, VEGFD) and down-regulation of catagen (transition phase) inducers (BMP4, DKK1, TGFB1) in at least 2 out of 3 donors. This suggests that Ash-ELN promotes hair growth by modulating pathways involved in anagen/catagen transition, making plant-derived exosomes a promising alternative for hair loss therapies.

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