Association Between Hair Proliferation and Flavonoid Silibinin in Human Dermal Papilla Cells

    September 2019 in “ Journal of Investigative Dermatology
    Kyu Joong Ahn, Jongmin Lee, Sooyoung Kim, Jung Min Hong, Jooyoun Kim, Jung Min Hong, Hye In Cheon, Mina Hur, Y. Lee, Yong Beom Choe
    TLDR Silibinin may help promote hair growth and treat hair loss.
    The study investigated the potential of silibinin, a compound from Silybum marianum, as a treatment for alopecia by examining its effects on human dermal papilla cells. The research found that silibinin increased the size of these cells, elevated AKT protein levels, and activated the Wnt/β-catenin signaling pathway, which is associated with hair proliferation. Additionally, silibinin upregulated key genes such as VCAN, FGF7, BMP2, and ALPL. These findings suggested that silibinin could be an effective therapeutic agent for promoting hair growth and treating alopecia.
    Discuss this study in the Community →

    Related Community Posts Join

    0 / 0 results
    — no results

    Similar Research

    5 / 32 results