Association Between Hair Proliferation and Flavonoid Silibinin in Human Dermal Papilla Cells

The study investigated the potential of silibinin, a compound from Silybum marianum, as a treatment for alopecia by examining its effects on human dermal papilla cells. The research found that silibinin increased the size of these cells, elevated AKT protein levels, and activated the Wnt/β-catenin signaling pathway, which is associated with hair proliferation. Additionally, silibinin upregulated key genes such as VCAN, FGF7, BMP2, and ALPL. These findings suggested that silibinin could be an effective therapeutic agent for promoting hair growth and treating alopecia.