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    Glossary RSPO1

    protein regulating hair growth and skin development

    RSPO1, or R-spondin 1, is a protein that plays a crucial role in the regulation of hair growth and skin development. It activates the Wnt signaling pathway, which is essential for the proliferation and differentiation of hair follicle cells. Mutations in the RSPO1 gene can lead to conditions like palmoplantar hyperkeratosis and predispose individuals to certain types of alopecia.

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    Research 30 of 141

    1. RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development Orphanet journal of rare diseases · 2022 · 5 citations
    2. RSPO1, a potent inducer of pancreatic β cell neogenesis Cell Reports Medicine · 2025 · 1 citations
    3. H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development Epigenetics & Chromatin · 2025 · 1 citations
    4. Management of a Refractory EIF3E-RSPO2 Fusion Positive Pilomatrical Cancer Patient with Encyclopedic Tumor Analysis Guided Treatment Acta Scientific Cancer Biology · 2020
    5. The role of R-spondins and their receptors in bone metabolism Progress in Biophysics & Molecular Biology · 2016 · 25 citations
    6. Synchronous profiling and analysis of mRNAs and ncRNAs in the dermal papilla cells from cashmere goats BMC genomics · 2019 · 17 citations
    7. Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells Frontiers in Cell and Developmental Biology · 2020 · 8 citations
    8. Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway Acta Biochimica et Biophysica Sinica · 2023 · 8 citations
    9. Effects of watercress extract fraction on R‐spondin 1‐mediated growth of human hair International Journal of Cosmetic Science · 2022 · 4 citations
    10. Interpretation of the Yak Skin Single-Cell Transcriptome Landscape Animals · 2023
    11. Sensitive Quantitative In Vivo Assay for Evaluating the Effects of Biomolecules on Hair Growth and Coloring Using Direct Microinjections into Mouse Whisker Follicles Biomolecules · 2023
    12. ISID1420 - Ashwagandha-derived exosome-like nanoparticles promote human hair growth ex vivo 2023
    13. 1420 Ashwagandha-derived exosome-like nanoparticles promote human hair growth ex vivo Journal of Investigative Dermatology · 2023
    14. The overexpression of R-spondin 3 affects hair morphogenesis and hair development along with the formation and maturation of the hair follicle stem cells Frontiers in Physiology · 2024 · 6 citations
    15. High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth Communications Biology · 2026
    16. High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth Research Square (Research Square) · 2024
    17. 189 Integrating single-cell and spatial transcriptomics of human hair follicles to define transcriptional signature of follicular dermal papilla 2022
    18. Characterizing the cellular diversity and molecular signatures within the hair follicle dermal stem cell lineage PRISM (University of Calgary) · 2017
    19. Clinical Snippets Experimental Dermatology · 2016
    20. Clinical Snippets Journal of Investigative Dermatology · 2016
    21. Genetic Mapping Of Hereditary Ectodermal Dysplasias And Hair Loss Genes 2011
    22. Investigating the mechanisms underlying age-related dysfunctions in skin and hair follicle regeneration 2020
    23. The developmental basis of fingerprint pattern formation and variation Cell · 2023 · 44 citations
    24. The Localization of Label-Retaining Cells in Mouse Nails Journal of Investigative Dermatology · 2007 · 22 citations
    25. Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure Scientific Reports · 2016 · 48 citations
    26. Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells Molecules · 2020 · 5 citations
    27. The Rotterdam Study: 2016 objectives and design update European Journal of Epidemiology · 2015 · 336 citations
    28. The Harmonies Played by TGF-β in Stem Cell Biology Cell Stem Cell · 2012 · 156 citations
    29. Wnt signaling: the good and the bad Acta Biochimica et Biophysica Sinica · 2008 · 48 citations
    30. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018 · 43 citations