Investigating the Safety and Efficacy of Platelet-Rich Plasma Treatment for Female Androgenetic Alopecia: Review of the Literature

March 2021 in “ Medicina-lithuania ”

Santo Raffaele Mercuri, Giovanni Paolino, M. Di Nicola, Laura Vollono

platelet-rich plasma PRP female androgenetic alopecia AGA hair growth hair density

TLDR PRP treatment may promote hair growth and improve hair density in women with AGA, but more research is needed.

This document is a review of studies on the safety and effectiveness of platelet-rich plasma (PRP) treatment for female androgenetic alopecia (AGA). The studies suggest that PRP may be effective in promoting hair growth and improving hair density in women with AGA, but more research is needed to determine the optimal treatment protocol and establish long-term safety and efficacy. Overall, PRP treatment appears to be a promising option with minimal side effects and high patient satisfaction rates, but larger, well-designed studies are needed to fully evaluate its effectiveness.

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55 / 55 results

research Comparison Between Single- Versus Double-Spin Prepared Platelet-Rich Plasma Injection in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor

10 citations , September 2021 in “Archives of Dermatological Research”

Both methods improve hair density and thickness; double-spin may be more effective.

research The Effect of Platelet-Rich Plasma on Female Androgenetic Alopecia: A Randomized Controlled Trial

18 citations , November 2020 in “Journal of The American Academy of Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research Platelet-Rich Plasma for Androgenetic Alopecia: Efficacy Differences Between Men and Women

10 citations , November 2020 in “Dermatologic Therapy”

PRP improves hair thickness for both genders, but only increases hair density in men.

research Evaluation of Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia: A Randomized Controlled Trial

33 citations , November 2020 in “Journal of The American Academy of Dermatology”

PRP treatment improves hair density and thickness for alopecia, but needs more research.

research A Systematic Review of the Effect of Platelet-Rich Plasma on Androgenetic Alopecia in Women

11 citations , July 2020 in “Dermatologic Therapy”

PRP treatment improves hair density and diameter in women with androgenetic alopecia.

research A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia

20 citations , July 2020 in “Expert Opinion on Biological Therapy”

Using micro-needling, low-level laser therapy, and platelet-rich plasma together significantly improves hair growth in people with hair loss.

research Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss

3 citations , July 2020 in “Indian Journal of Dermatology”

research A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women

22 citations , June 2020 in “Dermatologic Surgery”

Both Platelet-Rich Plasma and Minoxidil foam increase hair count in women with hair loss, but Minoxidil is more effective. However, women were more satisfied with Platelet-Rich Plasma treatment.

research Female Androgenetic Alopecia: An Update on Diagnosis and Management

43 citations , February 2020 in “American Journal of Clinical Dermatology”

FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.

research Trichologic Response of Platelet-Rich Plasma in Androgenetic Alopecia Is Maintained During Combination Therapy

15 citations , February 2020 in “Journal of The American Academy of Dermatology”

PRP therapy improves hair density and thickness in AGA patients, even with other treatments.

research Platelet-Rich Plasma and Its Utilities in Alopecia: A Systematic Review

21 citations , January 2020 in “Dermatologic Surgery”

Platelet-rich plasma (PRP) treatment has been found effective in promoting hair growth for alopecia patients, with minimal side effects like temporary pain and redness.

research Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia

39 citations , October 2019 in “Dermatologic Surgery”

PRP therapy increases hair density for androgenetic alopecia.

research Efficacy of Platelet-Rich Plasma for Treating Androgenic Alopecia of Varying Grades

19 citations , September 2019 in “Clinical Drug Investigation”

Platelet-rich plasma injections significantly improve hair density and thickness in both male and female pattern hair loss, especially in early stages.

research Minoxidil And Its Use In Hair Disorders: A Review

117 citations , August 2019 in “Drug Design Development and Therapy”

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

research HSD3B1 Gene Polymorphism and Female Pattern Hair Loss in Women with Polycystic Ovary Syndrome

7 citations , August 2019 in “Journal of the Formosan Medical Association”

HSD3B1 gene variant and being overweight linked to hair loss in women with polycystic ovary syndrome.

research Efficacy of Platelet-Rich Plasma in Androgenetic Alopecia Patients

14 citations , August 2019 in “Journal of Cosmetic Dermatology”

PRP therapy safely improves hair growth in people with hair loss.

research Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee

49 citations , July 2019 in “The Journal of Clinical Endocrinology and Metabolism”

Use "female pattern hair loss" term, assess androgen excess, treat with minoxidil and other medications if needed.

research Correlation of Trichoscopic Findings in Androgenetic Alopecia and the Disease Severity

12 citations , May 2019 in “International Journal of Trichology”

research HRQoL in Hair Loss-Affected Patients with Alopecia Areata, Androgenetic Alopecia, and Telogen Effluvium: The Role of Personality Traits and Psychosocial Anxiety

29 citations , March 2019 in “Journal of The European Academy of Dermatology and Venereology”

Personality traits and anxiety affect hair loss patients' quality of life.

research Platelet-Rich Plasma on Female Androgenetic Alopecia: Tested on 10 Patients

25 citations , February 2019 in “Journal of Cosmetic Dermatology”

PRP injections increase hair density and diameter in female androgenetic alopecia patients.

research The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study

52 citations , February 2018 in “Journal of Cosmetic Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

145 citations , January 2018 in “Journal of The European Academy of Dermatology and Venereology”

Use minoxidil for hair loss treatment; assess results after 6 months.

research Genetics and Other Factors in the Etiology of Female Pattern Hair Loss

43 citations , June 2017 in “Experimental Dermatology”

Female pattern hair loss has unclear causes, possibly involving genetics, hormones, and environment, and needs better treatments.

research Platelet-Rich Plasma in Combination With 5% Minoxidil Topical Solution and 1 mg Oral Finasteride for the Treatment of Androgenetic Alopecia: A Randomized Placebo-Controlled, Double-Blind, Half-Head Study

19 citations , May 2017 in “Dermatologic Surgery”

Combining platelet-rich plasma with 5% minoxidil solution improves hair regrowth in androgenetic alopecia patients.

research Platelet-Rich Plasma for the Treatment of Female Pattern Hair Loss: A Patient Survey

5 citations , April 2017 in “Dermatologic Surgery”

PRP treatment satisfies 58% of female hair loss patients, with most noticing fuller, thicker hair and less shedding.

research A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia

60 citations , December 2016 in “Dermatologic Surgery”

PRP treatment may stimulate hair growth by promoting blood vessel formation, increasing growth factors, and preventing cell death.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations , November 2016 in “Dermatologic Surgery”

PRP shows potential for treating female hair loss, but more research needed.

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations , April 2016 in “Dermatologic Surgery”

PRP treatment helps hair growth and density in androgenetic alopecia patients.

research Classifications of Patterned Hair Loss: A Review

101 citations , January 2016 in “Journal of Cutaneous and Aesthetic Surgery”

Different types of hair loss need specific treatments, and while many classification systems exist, each has its flaws; more research is needed to refine these systems and treatments.

research Demographics of Women with Female Pattern Hair Loss and the Effectiveness of Spironolactone Therapy

26 citations , October 2015 in “Journal of The American Academy of Dermatology”

Spironolactone may effectively treat female hair loss, especially with hyperandrogenism signs.

research Therapeutic Efficacy of Autologous Platelet-Rich Plasma and Polydeoxyribonucleotide on Female Pattern Hair Loss

54 citations , January 2015 in “Wound Repair and Regeneration”

PRP injections may improve hair thickness and density in female hair loss patients.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , October 2014 in “Journal of Cutaneous and Aesthetic Surgery”

PRP injections increase hair density and satisfaction in androgenetic alopecia patients.

research Evaluation and Diagnosis of the Hair Loss Patient

86 citations , September 2014 in “Journal of The American Academy of Dermatology”

To diagnose hair loss, use a systematic approach including history, exams, and tests.

research Platelet-Rich Plasma for Androgenetic Alopecia

107 citations , September 2014 in “Dermatologic Surgery”

PRP injections improve hair thickness for baldness.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , July 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research Investigation of Variants of the Aromatase Gene (CYP19A1) in Female Pattern Hair Loss

15 citations , September 2011 in “British Journal of Dermatology”

No link found between aromatase gene and female hair loss.

research Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update

87 citations , May 2011 in “Australasian Journal of Dermatology”

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

research Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss

53 citations , July 2010 in “PubMed”

Spironolactone helps regrow hair in women with hair loss.

research Validation of TrichoScan Technology as a Fully-Automated Tool for Evaluation of Hair Growth Parameters

38 citations , May 2009 in “European journal of dermatology/EJD. European journal of dermatology”

TrichoScan® is a reliable tool for measuring hair growth, providing quicker and more consistent results than manual methods.

research Use of the TrichoScan to Assess Female Pattern Hair Loss

30 citations , April 2009 in “Dermatologic Surgery”

TrichoScan helps identify subtle hair thinning in women with androgenetic alopecia.

research Dermoscopy in Female Androgenic Alopecia: Method Standardization and Diagnostic Criteria

129 citations , January 2009 in “International Journal of Trichology”

Trichoscopy can diagnose female hair loss with high accuracy by looking for specific patterns in hair and scalp appearance.

research Androgens and Hair Growth

209 citations , September 2008 in “Dermatologic Therapy”

Androgens can both increase and decrease hair growth in different parts of the body.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , February 2008 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

research Videodermoscopy in the Evaluation of Hair and Scalp Disorders

304 citations , November 2006 in “Journal of The American Academy of Dermatology”

Videodermoscopy improves diagnosis of hair and scalp disorders and may reduce scalp biopsies.

research Female Patients Complaining About Hair Loss: Documentation of Defective Scalp Hair Dynamics with Contrast-Enhanced Phototrichogram

23 citations , April 2006 in “Skin Research and Technology”

The study concluded that a special imaging technique showed women with hair loss have slower hair growth and a faulty hair replacement cycle.

research Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells

58 citations , January 2006 in “Skin Pharmacology and Physiology”

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

research Female Pattern Hair Loss and Its Relationship to Permanent/Cicatricial Alopecia: A New Perspective

73 citations , December 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Some women with common hair loss may develop permanent hair loss.

research The Reliability of Horizontally Sectioned Scalp Biopsies in the Diagnosis of Chronic Diffuse Telogen Hair Loss in Women

137 citations , August 2004 in “Journal of The American Academy of Dermatology”

Horizontally sectioned scalp biopsies are more reliable for diagnosing hair loss in women when three samples are taken instead of one.

research Androgenetic Alopecia in Women

139 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Androgenetic alopecia in women needs more research and better management strategies.

research Female Pattern Hair Loss

226 citations , September 2001 in “Journal of The American Academy of Dermatology”

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

research Role of Androgens in Female-Pattern Androgenetic Alopecia, Either Alone or Associated with Other Symptoms of Hyperandrogenism

47 citations , December 2000 in “Archives of Dermatological Research”

Androgens significantly affect female hair loss, and hormonal treatments may help.

research Female Androgenetic Alopecia: A Separate Entity

50 citations , July 2000 in “Dermatologic Surgery”

Female and male AGA are different diseases.

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations , March 1998 in “British Journal of Dermatology”

Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex

666 citations , September 1977 in “British Journal of Dermatology”

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.

9 / 9 results

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations , November 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss

1 citations , October 2022 in “PubMed”

Patients generally have positive attitudes towards using topical Minoxidil for hair loss treatment.

research Comprehensive Review of Oral Minoxidil in Alopecia

September 2022 in “Journal of Cosmetic Dermatology”

research Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis

1 citations , June 2021 in “Journal of Cosmetic Dermatology”

Using minoxidil and tofacitinib together can effectively treat severe hair loss.

research The Use of Trichoscopy to Assess the Efficacy of Topical Minoxidil 2% Solution in Patients with Female Pattern Hair Loss

April 2019 in “Zagazig university medical journal”