Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss

January 2020 in “ Indian Journal of Dermatology ”

Iman Seleit, Ola Ahmed Bakry, Eman A.E. Badr, Mai S. Mabrouk

Vitamin D Receptor VDR gene polymorphisms Taq-1 Cdx-1 Female Pattern Hair Loss FPHL anagen growth hair follicle stem cell proliferation gene variations hair growth phase hair stem cell growth

TLDR Certain gene variations in the Vitamin D Receptor are linked to higher risk of female hair loss.

The study investigated the association between Vitamin D Receptor (VDR) gene polymorphisms (Taq-1 and Cdx-1) and Female Pattern Hair Loss (FPHL) in 30 female patients and 30 age-matched healthy controls. It found that certain genotypes and alleles of Taq-1 (CC, TC, T) and Cdx-1 (AA, GA, G) were significantly more prevalent in FPHL patients, increasing disease risk by various folds (Taq-1: 12.6, 2.1, 2.9; Cdx-1: 7.5, 5.2, 5.5). The study concluded that these polymorphisms could be considered risk factors for FPHL, potentially affecting disease persistence by hindering new anagen growth and reducing hair follicle stem cell proliferation. Further research was recommended to confirm these findings.

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