Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia

    September 2023 in “ Medicine ”
    Hong-di Xiong, Lulu Tang, Chen Hai-ju … Youkun Lin
    Studysummary This study found increased infiltration of specific immune cells, such as γδ T cells and CD8+ T cells, in the bald scalp of male androgenetic alopecia patients, and identified four key immune-related genes potentially involved in hair loss development through interferon-γ signaling pathways.
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    Research cited in this study 13

    1. Association of Fibrosis in the Bulge Portion with Hair Follicle Miniaturization in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2021
    2. Androgens Downregulate BMP2, Impairing the Inductive Role of Dermal Papilla Cells on Hair Follicle Stem Cells Differentiation Molecular and Cellular Endocrinology · 2020
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    4. 6-Gingerol Inhibits Hair Cycle via Induction of MMP2 and MMP9 Expression Anais da Academia Brasileira de Ciências · 2017
    5. Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways British Journal of Dermatology · 2017
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    7. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
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    10. Identification of Clustered Cells in Human Hair Follicle Responsible for MMP-9 Gelatinolytic Activity: Consequences for the Regulation of Hair Growth International Journal of Dermatology · 2001
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