Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup

December 2024 in “ International Journal of Molecular Sciences ”

Mei Zheng, Seungchan An, In Guk Park, Jino Kim, Won-Serk Kim, Minsoo Noh, Jong-Hyuk Sung

CXCL12 androgenetic alopecia androgens dermal papilla cells dermal sheath cup cells androgen receptors hair miniaturization testosterone hair organ culture AGA DPCs DSCs AR

Studysummary This study observed that CXCL12 is highly co-expressed with androgen receptors in human hair follicle cells, and its inhibition via antibodies increased hair length, suggesting a potential treatment strategy for androgenic alopecia.

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