Heat-Treated Limosilactobacillus Fermentum LM1020 with Menthol, Salicylic Acid, and Panthenol Promotes Hair Growth and Regulates Scalp Microbiome Balance in Androgenetic Alopecia: A Double-Blind, Randomized, and Placebo-Controlled Clinical Trial

May 2024 in “ Journal of cosmetic dermatology ”

Won‐Young Bae, Woo‐Hyun Jung, So Lim Shin, T. W. Kim, Minn Sohn, Jangmi Suk, Inhee Jung, Young In Lee, Ju Hee Lee

Limosilactobacillus fermentum HT-LM1020 menthol salicylic acid panthenol androgenetic alopecia 5α-reductase cyclin B1 FGF7 FGF10 EGF7 lactic acid bacteria Staphylococcus caprae AGA 5-alpha-reductase fibroblast growth factor 7 fibroblast growth factor 10 epidermal growth factor 7

TLDR Heat-treated Limosilactobacillus fermentum with menthol, salicylic acid, and panthenol promotes hair growth and balances scalp microbiome in people with androgenetic alopecia.

The study investigated the effects of heat-treated Limosilactobacillus fermentum LM1020 (HT-LM1020) combined with menthol, salicylic acid, and panthenol on hair growth and scalp microbiome balance in patients with androgenetic alopecia (AGA). Conducted over 24 weeks, this double-blind, randomized, placebo-controlled clinical trial found that HT-LM1020 promoted cell growth and increased the expression of cyclin B1 while reducing 5α-reductase and inducing growth factors like FGF7, FGF10, and EGF7. The experimental group showed a significant increase in hair density from 133.70 to 148.87 n/cm² (p < 0.001) and reported satisfaction with hair density and reduced hair loss. Additionally, the scalp microbiome analysis revealed an increase in lactic acid bacteria and a decrease in Staphylococcus caprae. The results suggest that HT-LM1020 is effective in promoting hair growth and regulating scalp microbiome balance in AGA patients.

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