Heat-Treated Limosilactobacillus Fermentum LM1020 with Menthol, Salicylic Acid, and Panthenol Promotes Hair Growth and Regulates Scalp Microbiome Balance in Androgenetic Alopecia: A Double-Blind, Randomized, and Placebo-Controlled Clinical Trial

May 2024 in “ Journal of cosmetic dermatology ”

Won‐Young Bae, Woo‐Hyun Jung, So Lim Shin, T. W. Kim, Minn Sohn, Jangmi Suk, Inhee Jung, Young In Lee, Ju Hee Lee

Limosilactobacillus fermentum HT-LM1020 menthol salicylic acid panthenol androgenetic alopecia 5α-reductase cyclin B1 FGF7 FGF10 EGF7 lactic acid bacteria Staphylococcus caprae AGA 5-alpha-reductase fibroblast growth factor 7 fibroblast growth factor 10 epidermal growth factor 7

TLDR Heat-treated Limosilactobacillus fermentum with menthol, salicylic acid, and panthenol promotes hair growth and balances scalp microbiome in people with androgenetic alopecia.

This study demonstrated that a hair tonic containing heat-treated Limosilactobacillus fermentum LM1020 (HT-LM1020), menthol, salicylic acid, and panthenol significantly improved hair density and scalp microbiome balance in individuals with androgenetic alopecia (AGA). Conducted as a double-blind, randomized, placebo-controlled clinical trial with 50 participants, the experimental group showed a significant increase in hair density and microbiome diversity compared to the placebo group, with no adverse effects reported. HT-LM1020 also regulated key growth factors and reduced 5α-reductase gene expression, contributing to hair growth.

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