Beta-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

The study found that β-Nicotinamide Mononucleotide (NMN) promotes hair growth by reducing oxidative stress and regulating various cellular pathways. NMN was observed to reverse hair follicle atrophy, hair thinning, and hair sparsity induced by dihydrotestosterone (DHT), a hormone linked to hair loss. It was also found to protect human dermal papilla cells (HDPCs) from oxidative stress damage and inhibit the NF-κB p65 inflammatory signaling pathway. NMN enhanced the expression of Vascular Endothelial Growth Factor (VEGF), reduced IL-6 levels, suppressed the expression of AR and DKK-1, and notably increased β-catenin expression in DHT-induced HDPCs. These findings suggest that NMN could potentially be used as a treatment for hair loss.