Influencing Hair Regrowth With EGCG by Targeting Glycogen Synthase Kinase-3β Activity: A Molecular Dynamics Study

February 2025 in “ Journal of Receptors and Signal Transduction ”

Hamid Raza Moqaddasi, Anshul Singh, Shoma Mukherjee, F. Rezai, Arti Gupta, Saurabh Srivastava, Sathvik Belagodu Sridhar, Irfan Ahmad, Vivek Dhar Dwivedi, Sandeep Kumar

EGCG epigallocatechin gallate NMN nicotinamide mononucleotide Resveratrol glycogen synthase kinase-3β GSK3β hair regrowth hair follicle cycling alopecia green tea extract

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Studysummary In this study, computational analysis identified EGCG as the most effective GSK3β inhibitor among tested compounds, suggesting its potential for promoting hair regrowth by interacting with signaling pathways related to hair follicle cycling, although further experimental testing is needed.

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This study investigates the potential of EGCG, NMN, and Resveratrol as inhibitors of glycogen synthase kinase-3β (GSK3β) to promote hair regrowth. Using computational techniques, EGCG demonstrated the highest molecular docking scores and stability in dynamic simulations, maintaining stable interactions with GSK3β over 200 nanoseconds. EGCG showed significant inhibitory interaction, suggesting it could positively influence hair follicle cycling. These findings highlight EGCG as the most potent GSK3β inhibitor among the studied compounds, setting the stage for further experimental testing to explore its potential in treating alopecia.

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