Influencing Hair Regrowth With EGCG by Targeting Glycogen Synthase Kinase-3β Activity: A Molecular Dynamics Study

    February 2025 in “ Journal of Receptors and Signal Transduction ”
    Hamid Raza Moqaddasi, Anshul Singh, Shoma Mukherjee, F. Rezai, Arti Gupta, Saurabh Srivastava, Sathvik Belagodu Sridhar, Irfan Ahmad, Vivek Dhar Dwivedi, Sandeep Kumar
    TLDR EGCG may help regrow hair by inhibiting a specific enzyme.
    This study investigates the potential of EGCG, NMN, and Resveratrol as inhibitors of glycogen synthase kinase-3β (GSK3β) to promote hair regrowth. Using computational techniques, EGCG demonstrated the highest molecular docking scores and stability in dynamic simulations, maintaining stable interactions with GSK3β over 200 nanoseconds. EGCG showed significant inhibitory interaction, suggesting it could positively influence hair follicle cycling. These findings highlight EGCG as the most potent GSK3β inhibitor among the studied compounds, setting the stage for further experimental testing to explore its potential in treating alopecia.
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