Ginsenoside Re Prevents 3-Methyladenine-Induced Catagen Phase Acceleration by Regulating Wnt/Beta-Catenin Signaling in Human Dermal Papilla Cells

The study explores the impact of ginsenoside Re on autophagy and hair growth in human dermal papilla cells (hDPCs). Researchers found that ginsenoside Re enhances autophagy and counteracts the inhibition of Wnt/β-catenin signaling caused by 3-methyladenine (3-MA), which otherwise accelerates the catagen phase of hair follicles. This suggests that ginsenoside Re could be a promising therapeutic agent for hair loss by maintaining the anagen phase and promoting hair growth through the regulation of autophagy and Wnt/β-catenin signaling pathways. However, the study's reliance on 2D cell culture instead of 3D dermal papilla spheres is a noted limitation.