Panax Ginseng Extract Antagonizes the Effect of DKK-1-Induced Catagen-Like Changes of Hair Follicles

August 2017 in “ International Journal of Molecular Medicine ”

Yonghee Lee, Su Na Kim, Yong Deog Hong, Byung Cheol Park, Yongjoo Na

Panax ginseng DKK-1 catagen hair follicles apoptosis outer root sheath keratinocytes Bcl-2 Bax ex vivo human hair organ culture ginseng Dickkopf-1 hair loss ORS keratinocytes

TLDR Panax ginseng extract may help prevent hair loss caused by DKK-1.

The 2017 study found that Panax ginseng (PG) extract can mitigate the hair loss effects caused by Dickkopf-1 (DKK-1), which promotes catagen progression and apoptotic cell death in hair follicles (HFs). The extract was shown to stimulate proliferation and inhibit apoptosis in cultured outer root sheath (ORS) keratinocytes, as well as to regulate the expression of apoptosis-related genes by increasing Bcl-2 and decreasing Bax levels. Additionally, in an ex vivo human hair organ culture, PG extract reversed the catagen-like changes induced by DKK-1, suggesting its potential as a treatment for hair loss. The study did not specify the number of samples or participants used in the research.

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Research cited in this study

16 / 16 results

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research Panax Ginseng Extract Antagonizes the Effect of DKK-1-Induced Catagen-Like Changes of Hair Follicles

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Panax Ginseng Extract Antagonizes the Effect of DKK-1-Induced Catagen-Like Changes of Hair Follicles

Research cited in this study

research The Ginsenosides of Panax Ginseng Promote Hair Growth via Similar Mechanism of Minoxidil

research Evaluation of Apoptosis Regulatory Markers in Androgenetic Alopecia

research Preventable Effect of L-Threonate, an Ascorbate Metabolite, on Androgen-Driven Balding via Repression of Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Hair Dermal Papilla Cells

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

research Molecular Biology of Hair Morphogenesis: Development and Cycling

research Nestin Expression in Hair Follicle Sheath Progenitor Cells

research Promotion of Hair Growth by Ginseng Radix on Cultured Mouse Vibrissal Hair Follicles

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

research Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles

research Molecular Mechanisms Regulating Hair Follicle Development

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

research Hair Follicle Apoptosis And Bcl-2

research Panax Ginseng Prevents Apoptosis in Hair Follicles and Accelerates Recovery of Hair Medullary Cells in Irradiated Mice

research Human Hair Growth In Vitro: A Model for the Study of Hair Follicle Biology

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