Panax Ginseng Extract Antagonizes the Effect of DKK-1-Induced Catagen-Like Changes of Hair Follicles

    August 2017 in “ International Journal of Molecular Medicine ”
    Yonghee Lee, Su Na Kim, Yong Deog Hong, Byung Cheol Park, Yongjoo Na
    Image of study
    TLDR Panax ginseng extract may help prevent hair loss caused by DKK-1.
    The 2017 study found that Panax ginseng (PG) extract can mitigate the hair loss effects caused by Dickkopf-1 (DKK-1), which promotes catagen progression and apoptotic cell death in hair follicles (HFs). The extract was shown to stimulate proliferation and inhibit apoptosis in cultured outer root sheath (ORS) keratinocytes, as well as to regulate the expression of apoptosis-related genes by increasing Bcl-2 and decreasing Bax levels. Additionally, in an ex vivo human hair organ culture, PG extract reversed the catagen-like changes induced by DKK-1, suggesting its potential as a treatment for hair loss. The study did not specify the number of samples or participants used in the research.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 8 results

      community Panax Ginseng is effective against hair loss

       41 upvotes 4 years ago
      Panax Ginseng is suggested as effective against hair loss, with a recommended dose of 400-500mg/day. Users discuss its efficacy and side effects, with some noting no changes and others mentioning insomnia and other side effects.

      community Unexpected hairline re-growth (taking new supplements)

      in Treatment  32 upvotes 3 years ago
      A user in their mid-30s experienced unexpected hairline regrowth after starting a new supplement stack, despite being on a regimen of finasteride, minoxidil, and Nizoral for over four years. The new supplements include Tongkat Ali, Fadogia Agrestis, Panax Red Ginseng, Vitamin B1, Vitamin D3, Zinc Picolinate, Magnesium Glycinate, Maca, and L-Citrulline.

      community 30 M diffuse shining/bolding crown - stack

      in Treatment  1 upvotes 3 months ago
      A 30-year-old with diffuse thinning and a balding crown is using a treatment regimen of a 2-in-1 pill containing finasteride, minoxidil, and biotin, along with various supplements. After two weeks, no side effects have been experienced, and updates with pictures will be posted monthly.

    Related Research

    8 / 8 results