Heat-Killed Enterococcus Faecalis EF-2001 Induces Human Dermal Papilla Cell Proliferation and Hair Regrowth in C57BL/6 Mice

May 2022 in “ International journal of molecular sciences ”

Yong-Hyeon Baek, Jinho Lee, Sang-Jin Chang, Yuri Chae, Myung-Hun Lee, Sun-Hong Kim, Kwon-Il Han, Tack-Joong Kim

Enterococcus faecalis EF-2001 human dermal papilla cell HDPC hair regrowth C57BL/6 mice minoxidil hair-follicle conversion telogen anagen growth factors FGF2 FGF7 FGF10 VEGF-A VEGF-B marker genes Wnt10b EF-2001

Studysummary This study found that heat-killed Enterococcus faecalis EF-2001 promoted hair regrowth in mice, likely by increasing the expression of growth factors and marker genes.

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The study investigated the effects of heat-killed Enterococcus faecalis EF-2001 on hair regrowth and human dermal papilla cell (HDPC) proliferation using C57BL/6 mice. EF-2001 treatment led to a concentration-dependent increase in HDPC proliferation and promoted hair regrowth in mice, comparable to minoxidil. The treatment accelerated hair-follicle conversion from telogen to anagen by increasing the expression of growth factors (FGF2, FGF7, FGF10, VEGF-A, VEGF-B) and marker genes (Wnt10b). No side effects were observed, suggesting EF-2001 as a potential alternative to minoxidil for hair regrowth, though further studies are needed to confirm its long-term safety and mechanisms.

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