Heat-Killed Enterococcus Faecalis EF-2001 Induces Human Dermal Papilla Cell Proliferation and Hair Regrowth in C57BL/6 Mice

    Yong-Hyeon Baek, Jinho Lee, Sang-Jin Chang, Yuri Chae, Myung-Hun Lee, Sun-Hong Kim, Kwon-Il Han, Tack-Joong Kim
    TLDR Heat-killed Enterococcus faecalis EF-2001 may promote hair growth and transition hair follicles to the growth phase.
    The study investigated the effects of heat-killed Enterococcus faecalis EF-2001 on hair regrowth and human dermal papilla cell (HDPC) proliferation using C57BL/6 mice. EF-2001 treatment led to a concentration-dependent increase in HDPC proliferation and promoted hair regrowth in mice, comparable to minoxidil. The treatment accelerated hair-follicle conversion from telogen to anagen by increasing the expression of growth factors (FGF2, FGF7, FGF10, VEGF-A, VEGF-B) and marker genes (Wnt10b). No side effects were observed, suggesting EF-2001 as a potential alternative to minoxidil for hair regrowth, though further studies are needed to confirm its long-term safety and mechanisms.
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