In Vitro and In Vivo Hair Growth Promotion Effects of Lactobacillus Plantarum-Fermented Plant Extracts (MBN)

June 2011 in “ Han-guk sikpum gwahakoeji/Han'gug sigpum gwahag hoeji/Han-guk sikpum gwahak hoeji ”

주성수

Lactobacillus plantarum fermented plant extracts MBN hair growth C57BL/6 mice HaCaT cells VEGF KGF TGFβ1 nitric oxide blood flow vascular endothelial growth factor keratinocyte growth factor transforming growth factor beta 1

Studysummary This study found that MBN, an herbal extract fermented by Lactobacillus plantarum, promoted hair growth and increased related gene expression in C57BL/6 mice. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effects of Lactobacillus plantarum-fermented plant extracts (MBN) on hair growth in C57BL/6 mice and HaCaT cells. Mice treated with MBN topically for 21 days showed significant hair regrowth and increased hair thickness. Gene expression analysis revealed that VEGF and KGF were expressed in a dose-dependent manner, while TGFβ1 was not. Additionally, nitric oxide levels increased, indicating improved blood flow. These findings suggested that MBN effectively promoted hair growth and relevant gene expression in the animal model.

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