Promotional Effects of Sargassum Fusiforme Fractions on Hair Growth via In Vitro and In Vivo Models

June 2014 in “ Journal of biomedical research ”

Sung Kyu Jang, Seong Soo Joo

Sargassum fusiforme ethanol extract ethyl acetate fraction hair growth C57BL/6 mice HaCaT cells keratinocyte growth factor vascular endothelial growth factor transforming growth factor-beta1 ET FR KGF VEGF TGF-β1

TLDR Sargassum fusiforme extracts help promote hair growth.

The study investigated the effects of ethanol extract (ET) and ethyl acetate fraction (FR) of Sargassum fusiforme on hair growth using C57BL/6 mice and HaCaT cells. Over 21 days, ET and FR promoted hair regrowth in mice at doses >20 mg/kg, confirmed by macroscopic observation and tissue staining. Additionally, ET and FR stimulated the expression of keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF) mRNAs in a dose-dependent manner, while transforming growth factor-beta1 (TGF-β1) was not activated. These findings suggested that ET and FR effectively promoted hair growth and relevant gene expression in both in vitro and in vivo models.

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