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Glossary Transforming Growth Factor Beta

protein regulating cell growth, differentiation, and immune responses

Transforming Growth Factor Beta (TGF-β) is a protein that plays a crucial role in regulating cell growth, differentiation, and immune responses. It is involved in various biological processes, including wound healing and the development of fibrosis, and can influence hair growth by affecting the hair follicle cycle.

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Research

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research Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta

96 citations , December 2018 in “Immunity”

This study found that inhibiting TGF-β receptors in adult dermal fibroblasts restored their function and increased resistance to Staphylococcus aureus infection by enhancing their adipogenic and antimicrobial capabilities.

research Serum Levels of Transforming Growth Factor Beta1 (TGF β1) in Patients with Alopecia Areata.

July 2020 in “Benha Medical Journal”

This study found that patients with alopecia areata had higher serum TGF-β1 levels than controls, and these levels were associated with disease severity, suggesting a potential role in its pathogenesis.

research Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

56 citations , September 2013 in “Journal of Biochemistry and Molecular Biology”

This study observed that androgen treatment increased ROS production and TGF-β1 secretion in rat hair follicle dermal papilla cells, suggesting that the androgen-induced TGF-β1 is mediated by ROS.

research Expression of transforming growth factor-beta (TGF-beta 1) and insulin-like growth factor II (IGF-II) messenger RNA in the developing subcutaneous tissue (SQ) of the fetal pig.

11 citations , January 1992 in “PubMed”

In this study, the researchers found distinct patterns of TGF-beta 1 and IGF-II expression in pig fetal subcutaneous tissue, suggesting specific regulatory roles in developing adipocytes and muscle tissue.

research trans-3,4'-Dimethyl-3-hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor .BETA.2 (TGF-.BETA.2) through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes

10 citations , January 2008 in “Biological and Pharmaceutical Bulletin”

This study found that trans-3,4'-Dimethyl-3-hydroxyflavanone reduces active TGF-beta2 levels in human keratinocytes, suggesting it may enhance hair growth by suppressing the TGF-beta2 activation pathway.

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Community Join

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community Taurine supplements work for hair growth?

9 upvotes 2 years ago

The conversation discusses taurine supplements for hair growth, highlighting their potential to reduce DHT and improve hair health. A user comments that people often try alternatives to finasteride.

community A new study by Deng and colleagues set out to explore differences between balding and non balding scalps...

39 upvotes 4 years ago

Balding scalps have more androgen receptors, leading to increased TGF-beta, which causes blood vessel loss and hair follicle miniaturization. Blocking androgen signaling and TGF-beta may help prevent hair loss.

community Possible topical option for preventing BDNF-related hair loss

6 upvotes 2 years ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community Microneedling-induced shedding after 5 months?

in Progress Pictures 22 upvotes 10 months ago

A user experienced significant hair loss after starting microneedling, despite using dutasteride and topical minoxidil. They are advised to consult a doctor as the shedding pattern is unusual and may indicate alopecia areata or other scalp conditions.

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Learn

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learn Epidermal Growth Factor

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Vascular Endothelial Growth Factor

learn Platelet-Rich Plasma

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Stem Cell Factor

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