Evaluation of Hair Growth Promoting Activity of Sansevieria Trifasciata P. on Androgenic Alopecia in Male Rabbits
January 2021
in “
International journal of pharmaceutical research
”
Sansevieria trifasciata androgenic alopecia ethanol extract n-hexane fraction ethyl acetate water fraction modified Tanaka method hair follicle anagen/telogen ratio dihydrotestosterone DHT minoxidil hair regrowth terminal hair hair miniaturization snake plant androgenic hair loss ethyl acetate fraction water extract hair follicle proportion A/T ratio DHT hormone Rogaine hair growth anagen phase telogen phase
TLDR Sansevieria trifasciata P. extracts, especially the ethyl acetate fraction, effectively promote hair growth in male rabbits with hair loss.
The study conducted in 2021 aimed to evaluate the hair growth promoting activity of Sansevieria trifasciata P. on male rabbits with androgenic alopecia. The research involved the topical application of ethanol extract, n-hexane fraction, ethyl acetate, and water fraction of S. trifasciata P. (20% concentration each) on the rabbits. The hair growth length was assessed using the modified Tanaka method on 5 rabbits, while the microscopic image of rabbit skin tissue, hair follicle proportion, and the anagen/telogen (A/T) ratio were assessed using the modified Matias method on 3 rabbits induced by dihydrotestosterone hormone (DHT) for 21 days. The results showed that all the tested fractions significantly nourished hair and were as effective as a 2% minoxidil solution in promoting hair growth. The best hair growth length (2.07 cm ± 0.06) was observed in the group given the ethyl acetate fraction. The ethyl acetate fraction also showed better activity in hair growth as it led to hair regrowth at the shaved site, with a higher number of anagen (terminal hair) than telogen (hair miniaturization).
