Unveiling the Potential of Sansevieria Trifasciata Prain Fraction for the Treatment of Androgenetic Alopecia by Inhibiting Androgen Receptors Based on LC-MS/MS Analysis and In-Silico Studies

    July 2022 in “ Molecules ”
    Henny Kasmawati, Resmi Mustarichie, Eli Halimah … Nurramadhani A Sida
    Studysummary This study identified seven new compounds from the plant Sansevieria trifasciata Prain and predicted that four of them may have better anti-alopecia activity than minoxidil through an in silico approach.
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    Research cited in this study 27

    1. Antialopecia Activity and IR Spectrometry Characterization of Bioactive Compounds From Sansevieria Trifasciata Egyptian Journal of Chemistry · 2022
    2. Weekly Treatment with SAMiRNA Targeting the Androgen Receptor Ameliorates Androgenetic Alopecia Scientific Reports · 2022
    3. The Identification of Molecular Mechanisms from Bioactive Compounds in Sansevieria Trifasciata Plant as Anti-Alopecia: In-Silico Approach Rasayan journal of Chemistry · 2022
    4. Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls Clinical Interventions in Aging · 2021
    5. 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety Dermatologic Therapy · 2020
    6. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    7. Complementary and Alternative Treatments for Alopecia: A Comprehensive Review Skin appendage disorders · 2018
    8. Traction Alopecia: The Root of the Problem Clinical, cosmetic and investigational dermatology · 2018
    9. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    10. Interventions for Female Pattern Hair Loss The Cochrane library · 2016
    11. Hair Restoration in Androgenetic Alopecia: Looking Beyond Minoxidil, Finasteride, and Hair Transplantation Journal of cosmetology & trichology · 2016
    12. Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay BMC Complementary and Alternative Medicine · 2015
    13. Drug Discovery for Alopecia: Gone Today, Hair Tomorrow Expert Opinion on Drug Discovery · 2015
    14. Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia Expert Opinion on Therapeutic Targets · 2014
    15. Minoxidil May Suppress Androgen Receptor-Related Functions Oncotarget · 2014
    16. Androgenetic Alopecia: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    17. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    18. Interventions for Female Pattern Hair Loss Cochrane Database of Systematic Reviews · 2012
    19. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    20. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    21. Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia Archives of Dermatology · 2010
    22. Androgenetic Alopecia: Clinical Features, Classification, and Treatments Endocrinology and Metabolism Clinics of North America · 2007
    23. The Current Role of Laser and Light Sources in the Treatment of Male and Female Pattern Hair Loss Journal of Cosmetic and Laser Therapy · 2007
    24. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    25. The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003
    26. Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia) Dermatologic Surgery · 2001
    27. Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy Molecular Medicine Today · 1996

    Related research 5

    1. Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia European Journal of Pharmaceutics and Biopharmaceutics · 2022
    2. Minoxidil May Suppress Androgen Receptor-Related Functions Oncotarget · 2014
    3. Minoxidil to Treat Androgenetic Alopecia in Men and Women: What Is It and How Does It Work? American Journal of Medicine and Medical Sciences · 2014
    4. Rapid Determination of Minoxidil in Human Plasma Using Ion-Pair HPLC Journal of Pharmaceutical and Biomedical Analysis · 2004
    5. The Effect of Topical RU58841 (Androgen Receptor Blocker) Combined with Minoxidil on Hair Growth in Macaque Androgenetic Alopecia Journal of Dermatological Science · 1998