Unveiling the Potential of Sansevieria Trifasciata Prain Fraction for the Treatment of Androgenetic Alopecia by Inhibiting Androgen Receptors Based on LC-MS/MS Analysis and In-Silico Studies

    July 2022 in “ Molecules
    Henny Kasmawati, Resmi Mustarichie, Eli Halimah, Ruslin Ruslin, Arfan Arfan, Nurramadhani A Sida
    TLDR Sansevieria trifasciata Prain shows promise for treating hair loss by inhibiting androgen receptors.
    This study explores the potential of Sansevieria trifasciata Prain for treating androgenetic alopecia by inhibiting androgen receptors. Using LC-MS/MS and in-silico methods, seven compounds were identified, with four (Methyl pyrophaeophorbide A, Oliveramine, (2S)-3′, 4′-Methylenedioxy-5, 7-dimethoxyflavane, and 1-Acetyl-β-carboline) showing better binding energies and stability than minoxidil. Molecular docking and dynamics simulations confirmed the stability and effectiveness of these compounds in inhibiting androgen receptors, suggesting their potential as alternative treatments for androgenetic alopecia.
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