The Identification of Molecular Mechanisms from Bioactive Compounds in Sansevieria Trifasciata Plant as Anti-Alopecia: In-Silico Approach

This study explored the potential of bioactive compounds from the Sansevieria trifasciata plant as treatments for alopecia using in-silico methods. It focused on the interaction of these compounds with the androgen receptor (AR), which plays a role in androgenetic alopecia (AGA). Out of forty-nine compounds analyzed, three showed promising results in terms of stability, binding free energy, and pharmacokinetic profiles, with better performance than minoxidil, a standard AGA treatment. Two of these compounds were identified as steroids with strong binding to AR, suggesting they could inhibit the receptor's activity. They also had favorable pharmacokinetic properties, including low skin permeability and no CYP2D6 enzyme inhibition, were non-mutagenic, and mostly non-hepatotoxic. The study concludes that these compounds are promising candidates for further research to confirm their effectiveness against alopecia.