In-Silico Study of Bioactive Compounds of Natural Materials as a JAK-Signal Transducer and Activator of Transcription Inhibitor for Anti-Alopecia
November 2017
in “
Asian journal of pharmaceutical and clinical research
”
TLDR Three compounds from Dadap leaves may help treat hair loss.
This in-silico study aimed to identify bioactive compounds in herbs that could inhibit JAK2, a key regulator in hair follicle activation, for anti-alopecia treatment. Using molecular modeling and docking techniques, 15 compounds from five traditional hair growth herbs were analyzed. Three compounds—6-hydroxy genistein, coreximine, and scoulerine—showed strong interactions with JAK2's active pocket, suggesting their potential as anti-alopecia agents. These compounds, derived from Dadap leaves, should be further tested in vivo to confirm their efficacy in promoting hair growth.
