In-Silico Study of Bioactive Compounds of Natural Materials as a JAK-Signal Transducer and Activator of Transcription Inhibitor for Anti-Alopecia

November 2017 in “ Asian journal of pharmaceutical and clinical research ”

Resmi Mustarichie, Sandra Megantara, Nyi Mekar Saptarini

JAK2 hair follicle activation anti-alopecia molecular modeling docking techniques 6-hydroxy genistein coreximine scoulerine Dadap leaves JAK2 inhibitor hair growth herbs

TLDR Three compounds from Dadap leaves may help treat hair loss.

This in-silico study aimed to identify bioactive compounds in herbs that could inhibit JAK2, a key regulator in hair follicle activation, for anti-alopecia treatment. Using molecular modeling and docking techniques, 15 compounds from five traditional hair growth herbs were analyzed. Three compounds—6-hydroxy genistein, coreximine, and scoulerine—showed strong interactions with JAK2's active pocket, suggesting their potential as anti-alopecia agents. These compounds, derived from Dadap leaves, should be further tested in vivo to confirm their efficacy in promoting hair growth.

View this study on innovareacademics.in →

Discuss this study in the Community →

Similar Research

5 / 308 results

research The JAK/STAT Signaling Pathway: From Bench to Clinic

489 citations, November 2021 in “Signal Transduction and Targeted Therapy”

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

research Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Merremia Peltata as a Potential Anti-Alopecia Treatment

7 citations, April 2021 in “Journal of advanced pharmaceutical technology & research”

The compound 16 from the Merremia peltata plant could potentially be a good treatment for hair loss (alopecia) due to its strong activity and favorable skin absorption.

research How Our Microbiome Influences the Pathogenesis of Alopecia Areata

4 citations, October 2022 in “Genes”

Our microbiome may affect the development of the hair loss condition Alopecia Areata, but more research is needed to understand this relationship.

Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

research Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

1 citations, October 2022 in “International Journal of Molecular Sciences”

Using healthy donor stem cells can potentially calm overactive immune cells and reduce inflammation in severe hair loss patients, offering a possible treatment method.

research Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies

82 citations, March 2016 in “Autoimmunity reviews”

Animal models have helped understand hair loss from alopecia areata and find new treatments.