In-Silico Study of Bioactive Compounds of Natural Materials as a JAK-Signal Transducer and Activator of Transcription Inhibitor for Anti-Alopecia

November 2017 in “ Asian journal of pharmaceutical and clinical research ”

Resmi Mustarichie, Sandra Megantara, Nyi Mekar Saptarini

JAK2 hair follicle activation anti-alopecia molecular modeling docking techniques 6-hydroxy genistein coreximine scoulerine Dadap leaves JAK2 inhibitor hair growth herbs

TLDR Three compounds from Dadap leaves may help treat hair loss.

This in-silico study aimed to identify bioactive compounds in herbs that could inhibit JAK2, a key regulator in hair follicle activation, for anti-alopecia treatment. Using molecular modeling and docking techniques, 15 compounds from five traditional hair growth herbs were analyzed. Three compounds—6-hydroxy genistein, coreximine, and scoulerine—showed strong interactions with JAK2's active pocket, suggesting their potential as anti-alopecia agents. These compounds, derived from Dadap leaves, should be further tested in vivo to confirm their efficacy in promoting hair growth.

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