Antialopecia Activity Exploration by In-Silico Analysis of Bioactive Compounds from Sansevieria Trifasciata Prain Leaves Through 5α-Reductase Inhibition

This study investigates the potential of bioactive compounds from Sansevieria trifasciata Prain leaves as 5α-reductase inhibitors for alopecia treatment using in-silico analysis. Oliveramine and Methyl pyropheophorbide A showed the best binding affinities (-9.14 kcal/mol and -7.93 kcal/mol, respectively) and interacted with key residues Arg114 and Phe223. MM-PBSA analysis revealed their binding affinities (-146.472 kJ/mol and -120.004 kJ/mol) were superior to finasteride. Methyl pyropheophorbide A demonstrated stability and strong interactions, suggesting it as a promising candidate for further in vitro studies.