Anti-Alopecia Activity of Moringa (Moringa Oleifera Lamk.) Seed Oil Against Dihydrotestosterone-Induced Rabbits

    December 2023 in “ International Journal of Applied Pharmaceutics ”
    YULIUS BAKI KORASSA, Nyi Mekar Saptarini, Resmi Mustarichie, RINI HENDRIANI, Antonius R. B. Ola, YOAN NOVICADLITHA, Lely A. V. Kapitan
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    TLDR Moringa seed oil helped hair growth in rabbits, with the highest dose being most effective.
    The study investigated the potential of moringa seed oil as a treatment for alopecia in rabbits induced with dihydrotestosterone (DHT). Three concentrations of moringa seed oil (7.5%, 10%, and 12.5%) were tested alongside a positive control (0.1% finasteride) and a negative control (1% tween 80), measuring hair length and weight as outcomes. The results indicated that all concentrations of moringa seed oil exhibited anti-alopecia activity, with the 12.5% concentration showing the most promise. The average hair lengths for the 7.5%, 10%, and 12.5% concentrations were 3.4±0.17 cm, 3.9±0.20 cm, and 4.5±0.28 cm, respectively, while the average hair weights were 118±23 mg, 148±30.9 mg, and 175±47.2 mg. The 12.5% concentration of moringa seed oil was found to be optimal, as its effect on hair weight was statistically significant (p<0.05) when compared to the positive control, although the difference in hair length was not significant (p>0.05).
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