Effects of Cudrania Tricuspidata and Sargassum Fusiforme Extracts on Hair Growth in C57BL/6 Mice

February 2023 in “ Laboratory Animal Research ”

Priyanka Rajan, Premkumar Natraj, Nak Hyoung Kim, Jae-Hoon Kim, Hyuk Joon Choi, Chang-Hoon Han

Cudrania tricuspidata Sargassum fusiforme hair growth hair follicle anagen phase Catenin Beta 1 Ctnnb1 platelet-derived growth factor Pdgf vascular endothelial growth factor Vegf Wnts Oncostatin M Osm catagen phase telogen phase growth phase resting phase shedding phase

Studysummary This study found that Cudrania tricuspidata and Sargassum fusiforme extracts significantly increased hair growth and related gene activity in C57BL/6 mice, suggesting potential use in alopecia treatment. Our plain-language summary of this paper — not a Tressless recommendation.

The study found that both oral and topical application of Cudrania tricuspidata and Sargassum fusiforme extracts significantly increased hair growth rate and hair follicle length in C57BL/6 mice. This was achieved by upregulating genes associated with the anagen (growth) phase of hair growth, such as Catenin Beta 1 (Ctnnb1), platelet-derived growth factor (Pdgf), vascular endothelial growth factor (Vegf), and Wnts, and downregulating Oncostatin M (Osm), a gene associated with the catagen-telogen (resting and shedding) phases. The results suggest these extracts could potentially be used to develop treatments for hair loss.

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