Effects of Cudrania Tricuspidata and Sargassum Fusiforme Extracts on Hair Growth in C57BL/6 Mice

February 2023 in “ Laboratory Animal Research ”

Priyanka Rajan, Premkumar Natraj, Nak Hyoung Kim, Jae-Hoon Kim, Hyuk Joon Choi, Chang-Hoon Han

Cudrania tricuspidata Sargassum fusiforme hair growth hair follicle anagen phase Catenin Beta 1 Ctnnb1 platelet-derived growth factor Pdgf vascular endothelial growth factor Vegf Wnts Oncostatin M Osm catagen phase telogen phase growth phase resting phase shedding phase

TLDR Cudrania tricuspidata and Sargassum fusiforme extracts improved hair growth in mice by affecting growth-related genes.

The study found that both oral and topical application of Cudrania tricuspidata and Sargassum fusiforme extracts significantly increased hair growth rate and hair follicle length in C57BL/6 mice. This was achieved by upregulating genes associated with the anagen (growth) phase of hair growth, such as Catenin Beta 1 (Ctnnb1), platelet-derived growth factor (Pdgf), vascular endothelial growth factor (Vegf), and Wnts, and downregulating Oncostatin M (Osm), a gene associated with the catagen-telogen (resting and shedding) phases. The results suggest these extracts could potentially be used to develop treatments for hair loss.

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