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Hallmark Evidence of Lipopolysaccharide Tolerance in Obese Women with Polycystic Ovary Syndrome: LPS-Induced NFkB Suppression in Mononuclear Cells Linked to Hyperandrogenism

research Hallmark evidence of lipopolysaccharide (LPS) tolerance in obese women with polycystic ovary syndrome (PCOS) - LPS-induced NFkB suppression in mononuclear cells (MNC) is linked to hyperandrogenism in PCOS

September 2018 in “Fertility and Sterility”

This study found that in women with PCOS, lipid-induced NFκB activation is independent of obesity and exhibited evidence of LPS tolerance in combination with obesity and hyperandrogenism.

Effects of Parthenolide on Androgenetic Alopecia in Mice and Human Follicle Dermal Papilla Cells

research Selected Abstracts

January 2008 in “Annals of Nutrition and Metabolism”

This study suggests that a specific region upstream of the TGF-β1 gene may play a key role in androgenetic alopecia by regulating gene expression in a cell-specific manner.

research Ectoderm-Targeted Overexpression of the Glucocorticoid Receptor Induces Hypohidrotic Ectodermal Dysplasia

46 citations , March 2005 in “Endocrinology”

In this study, ectoderm-targeted transgenic mice with glucocorticoid receptor overexpression exhibited multiple epithelial defects, suggesting the role of NF-kappaB and p63 dysfunction in ectodermal dysplasia syndromes.

research Genome-wide shifts in gene expression induced in theca-interstitial cells by inflammatory stimuli

September 2018 in “Fertility and Sterility”

This study observed that inflammatory stimuli significantly altered gene expression in rat theca-interstitial cells, affecting pathways related to growth and androgen production, which are central features of polycystic ovary syndrome.

research Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair

52 citations , April 2013 in “Developmental Cell”

This study found that Brg1, a chromatin-remodeling enzyme, plays a critical role in hair regeneration and early epidermal repair by regulating bulge stem cells through a Brg1-Shh interaction.

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