Clinical Response to Adjunctive Platelet-Rich Plasma Injections in a Patient with Alopecia Universalis on Oral Tofacitinib

    December 2021 in “ JAAD case reports ”
    Sophia A. Ederaine, Carolyn J. Kushner, Jerry Shapiro, Kristen Lo Sicco
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    TLDR A woman with severe hair loss saw significant hair regrowth after adding platelet-rich plasma injections to her treatment with tofacitinib.
    The document presents a case of a 31-year-old woman with alopecia universalis (AU), a severe form of hair loss, who did not respond to oral tofacitinib and intralesional corticosteroids but showed significant improvement with the addition of platelet-rich plasma therapy (PRP) to oral tofacitinib. The patient began to exhibit hair loss 1 year before the treatment and had no response to two 30-day prednisone tapers. After 7 months of treatment with tofacitinib and corticosteroids with no response, PRP therapy was added to the regimen, and significant hair regrowth was noted after 4 months of monthly adjunctive PRP therapy. The document suggests that PRP injections can be an effective adjuvant therapy with tofacitinib for treatment-resistant AU, and further studies are needed to assess the systemic effects of PRP.
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