TLDR Understanding how keratin structures in hair are arranged and interact is key for creating methods to extract and purify them.
The document discusses the complexity of keratin as a biomaterial, emphasizing that hair follicles are composed of various types of keratins and keratin associated proteins (KAPs) that self-assemble into a molecular composite with distinct compartments like the cortex and cuticle. It highlights the importance of understanding the physical arrangement, interactions, and composite nature of keratin fibers for designing effective extraction and purification protocols. The keratins in hair are particularly noted for their high cysteine content and the extent of disulfide crosslinking, which is significant for their properties. The document also mentions oxidative sulfitolysis as a method for processing keratin, which is a hybrid chemical process involving both oxidation and reduction.
47 citations,
September 2011 in “Acta biomaterialia” Protein composition greatly affects the function of keratin biomaterials.
140 citations,
August 2011 in “Biomaterials” Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.
53 citations,
July 2011 in “Biomaterials” Human liver cells stick to hair protein materials mainly through the liver's asialoglycoprotein receptor.
99 citations,
June 2011 in “Journal of biomedical materials research. Part A” Keratin hydrogels can slowly release effective ciprofloxacin to prevent infections.
89 citations,
September 2010 in “Annual Review of Genomics and Human Genetics” The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.
49 citations,
April 2010 in “International Journal of Cosmetic Science” 309 citations,
October 2007 in “Biomaterials” Keratin from human hair helps nerves heal faster.
224 citations,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” The document concludes that understanding hair follicle biology can lead to better hair loss treatments.
1 citations,
February 2013 in “InTech eBooks” Genetic mutations cause various hair diseases, and whole genome sequencing may reveal more about these conditions.
38 citations,
October 2011 in “Analytical biochemistry” Hair proteins have weak spots in their α-helical segments.
48 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair growth is controlled by specific gene clusters and proteins, and cysteine affects hair gene expression in sheep.
30 citations,
August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” TGase 3 helps build hair structure by forming strong bonds between proteins.
10 citations,
November 2021 in “International journal of molecular sciences” Sheep and goat hair fibers are complex due to keratin-associated proteins, which are important for fiber properties and growth.
