Keratin

October 2016

Mark Van Dyke

keratin hair follicles keratin associated proteins KAPs cortex cuticle cysteine disulfide crosslinking oxidative sulfitolysis disulfide bonds

Studysummary This article reviews the complex structure and molecular composition of hair keratins, highlighting their self-assembly process and implications for keratin extraction techniques, but reports no new experimental results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

14 / 14 results

research The Effect of Human Hair Keratin Hydrogel on Early Cellular Response to Sciatic Nerve Injury in a Rat Model

105 citations , May 2013 in “Biomaterials”

In this study, the researchers found that a keratin hydrogel filler in nerve conduits led to earlier Schwann cell migration and improved cellular behaviors compared to other fillers in a rat sciatic nerve model.

research Hemostatic Properties and the Role of Cell Receptor Recognition in Human Hair Keratin Protein Hydrogels

118 citations , January 2013 in “Biomaterials”

This study characterized keratin-based biomaterials that self-assemble into hydrogels, demonstrating their potential to achieve hemostasis in a lethal liver injury model through specific biomaterial-receptor interactions.

research Structure–Property Relationships of Meta-Kerateine Biomaterials Derived from Human Hair

47 citations , September 2011 in “Acta biomaterialia”

This study observed that increasing the γ-kerateine content in meta-kerateine materials led to reduced elasticity, solidity, and hydrolytic stability, and decreased hepatocyte attachment support.

research Mechanical and Biological Properties of Keratose Biomaterials

140 citations , August 2011 in “Biomaterials”

This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.

research Mechanisms of Hepatocyte Attachment to Keratin Biomaterials

53 citations , July 2011 in “Biomaterials”

This study observed that hepatocyte adhesion to human hair keratin biomaterials was mediated by the hepatic ASGPR, as blocking this receptor reduced cell attachment.

research Keratin Hydrogels Support the Sustained Release of Bioactive Ciprofloxacin

99 citations , June 2011 in “Journal of biomedical materials research. Part A”

This study observed that keratose hydrogels sustained ciprofloxacin release over three weeks and inhibited Staphylococcus aureus growth in vitro for 23 days and in mice for 2 weeks.

research Biology and Genetics of Hair

89 citations , September 2010 in “Annual Review of Genomics and Human Genetics”

This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.

research Chronological Aging of Human Hair Keratin Fibers

49 citations , April 2010 in “International Journal of Cosmetic Science”

This study details how very long human hair naturally ages, showing cuticle wear and internal fiber changes that may inform new hair care product designs.

research Effect of Keratin-Gelatin and bFGF-Gelatin Composite Film as a Sandwich Layer for Full-Thickness Skin Mesh Graft in Experimental Dogs

50 citations , December 2007 in “Journal of Biomedical Materials Research Part B Applied Biomaterials”

In this study, the combination of keratin-gelatin from poultry feathers promoted early acceptance and viability of full-thickness skin mesh grafts in experimental dogs compared to other treatments.

research The Use of Keratin Biomaterials Derived from Human Hair for the Promotion of Rapid Regeneration of Peripheral Nerves

309 citations , October 2007 in “Biomaterials”

This study found that a biomaterial gel made from human hair keratins facilitated nerve regeneration in an animal model, potentially matching the effectiveness of traditional autografts.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.

research Human Hair Keratin-Associated Proteins

226 citations , January 2006 in “International review of cytology”

Keratin-associated proteins are crucial for hair strength and structure.

research A Rapid Extraction Procedure of Human Hair Proteins and Identification of Phosphorylated Species

226 citations , January 2002 in “Biological and Pharmaceutical Bulletin”

This study developed a rapid method to extract proteins from human hair, revealing phosphorylation on serine and threonine residues in alpha-keratins and matrix proteins.

research Regulation of Keratin Gene Expression in Hair Follicle Differentiation

98 citations , December 1991 in “Annals of the New York Academy of Sciences”

This study found that conserved DNA motifs and expression patterns in keratin genes suggest functional regulatory similarities in hair follicle differentiation across different mammalian species.