Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

    January 2012 in “ Biological & pharmaceutical bulletin ”
    Masayuki Chuma, Kaori Endo‐Umeda, Shigeki Shimba … Makoto Makishima
    Studysummary This study found that the protein hairless acts as both a corepressor and coactivator of the vitamin D receptor, influencing gene transcription in a ligand-selective manner.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jstage.jst.go.jp →
    Discuss this study in the Community →

    Research cited in this study 11

    1. Mechanism of JmjC-Containing Protein Hairless in the Regulation of Vitamin D Receptor Function Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2011
    2. Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice Journal of Cellular Physiology · 2010
    3. Analysis of Hairless Corepressor Mutants to Characterize Molecular Cooperation with the Vitamin D Receptor in Promoting the Mammalian Hair Cycle Journal of Cellular Biochemistry · 2010
    4. Vitamin D and the Skin Journal of bone and mineral metabolism · 2010
    5. Interactions of the Vitamin D Receptor with the Corepressor Hairless Journal of Biological Chemistry · 2007
    6. Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology · 2005
    7. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004
    8. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    9. The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor Genes & Development · 2001
    10. Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis Nature · 2000
    11. The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed Journal of bone and mineral research · 1998