Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

    January 2012 in “ Biological & pharmaceutical bulletin ”
    Masayuki Chuma, Kaori Endo‐Umeda, Shigeki Shimba, Sachiko Yamada, Makoto Makishima
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    TLDR Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.
    The study investigated the role of Hairless (HR) as a coregulator of the vitamin D receptor (VDR) and its impact on VDR activation by 1α,25-dihydroxyvitamin D(3) and lithocholic acid (LCA). HR was found to repress VDR transactivation induced by both ligands and also affected VDR mutants involved in retinoid X receptor (RXR) heterodimer communication. HR enhanced the association of VDR with a corepressor, indicating its role in VDR-RXR allosteric communication and corepressor complex formation. HR knockdown in keratinocyte-derived cells showed that HR acts as both a corepressor and coactivator, influencing gene-selective transcription regulation.
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