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    Glossary Lithocholic acid

    secondary bile acid produced by intestinal bacteria

    Lithocholic acid (LCA) is a secondary bile acid produced in the intestines by bacterial action on primary bile acids. It plays a role in the digestion and absorption of fats and fat-soluble vitamins, but high levels of LCA can be toxic to liver cells and have been linked to certain diseases, including liver cancer.

    Research 10 of 28

    1. 698 Effect of lithocholic acid as a ligand of vitamin D receptor on hair growth in alopecia Journal of Investigative Dermatology · 2016
    2. Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer Biological & pharmaceutical bulletin · 2012 · 28 citations
    3. 700 Oncostatin M is upstream of JAK-STAT signaling during the murine hair cycle Journal of Investigative Dermatology · 2016
    4. 702 dsRNA induces ectopic KRT9 expression via WNT/β-catenin-mediated signaling Journal of Investigative Dermatology · 2016
    5. Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism bioRxiv (Cold Spring Harbor Laboratory) · 2026
    6. Vitamin D resistance 2006 · 45 citations
    7. Very-long-chain Acyl-CoA Synthetases Journal of Biological Chemistry · 2007 · 191 citations
    8. Gut microbiota-derived metabolites in keloid and hypertrophic scarring Frontiers in Microbiology · 2025 · 3 citations
    9. The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review Metabolites · 2023 · 1 citations
    10. Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia Scientific Reports · 2017 · 20 citations
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