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    Glossary Lithocholic acid

    secondary bile acid produced by intestinal bacteria

    Lithocholic acid (LCA) is a secondary bile acid produced in the intestines by bacterial action on primary bile acids. It plays a role in the digestion and absorption of fats and fat-soluble vitamins, but high levels of LCA can be toxic to liver cells and have been linked to certain diseases, including liver cancer.

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    Research 28

    1. 698 Effect of lithocholic acid as a ligand of vitamin D receptor on hair growth in alopecia Journal of Investigative Dermatology · 2016
    2. Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer Biological & pharmaceutical bulletin · 2012 · 28 citations
    3. 700 Oncostatin M is upstream of JAK-STAT signaling during the murine hair cycle Journal of Investigative Dermatology · 2016
    4. 702 dsRNA induces ectopic KRT9 expression via WNT/β-catenin-mediated signaling Journal of Investigative Dermatology · 2016
    5. Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism bioRxiv (Cold Spring Harbor Laboratory) · 2026
    6. Vitamin D resistance 2006 · 45 citations
    7. Very-long-chain Acyl-CoA Synthetases Journal of Biological Chemistry · 2007 · 191 citations
    8. Gut microbiota-derived metabolites in keloid and hypertrophic scarring Frontiers in Microbiology · 2025 · 3 citations
    9. The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review Metabolites · 2023 · 1 citations
    10. Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia Scientific Reports · 2017 · 20 citations
    11. Eph Receptors and Ephrins: Therapeutic Opportunities Annual Review of Pharmacology and Toxicology · 2014 · 222 citations
    12. Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications Medical Review · 2024 · 6 citations
    13. 699 Effect of Prostaglandin D 2 on hair follicle growth and its impact on hair follicle stem/progenitor cells Journal of Investigative Dermatology · 2016 · 1 citations
    14. 703 Anti-aging potential of gypenosides fraction obtained from naturally grown Gynostemma pentaphyllum in Ulleungdo Island and its 7 new gypenosides Journal of Investigative Dermatology · 2016
    15. Vitamin D, Lipid Metabolism and Prostate Cancer Trepo - Institutional Repository of Tampere University · 2009 · 1 citations
    16. Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome Nature Clinical Practice Endocrinology & Metabolism · 2005 · 69 citations
    17. A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia Endocrinology · 2014 · 25 citations
    18. The Molecular Biology of the Vitamin D Receptor Humana Press eBooks · 2010 · 22 citations
    19. Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling Journal of Biological Chemistry · 2003 · 215 citations
    20. Advancements and challenges in stem cell transplantation for regenerative medicine Heliyon · 2024 · 55 citations
    21. The 1,25-dihydroxyvitamin D3-independent actions of the vitamin D receptor in skin 2010 · 18 citations
    22. Stem Cells Applications in Regenerative Medicine and Disease Therapeutics International Journal of Cell Biology · 2016 · 606 citations
    23. Vitamin D: More Than a “Bone-a-Fide” Hormone Molecular endocrinology · 2003 · 276 citations
    24. Evidence for 1,25-Dihydroxyvitamin D3-independent Transactivation by the Vitamin D Receptor 2007 · 36 citations
    25. The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs Microorganisms · 2022 · 9 citations
    26. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women Bioscience Reports · 2020 · 1 citations
    27. The Potential Application of Nanocarriers in Delivering Topical Antioxidants Pharmaceuticals · 2025
    28. Follicular Fluid: A Powerful Tool for the Understanding and Diagnosis of Polycystic Ovary Syndrome Biomedicines · 2022 · 45 citations