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GlossaryDeoxycholic Acid

bile acid aiding fat digestion and absorption

Deoxycholic Acid, also known as DCA, is a bile acid that is naturally produced by the liver and stored in the gallbladder. It helps in the digestion and absorption of fats in the small intestine. In medical and cosmetic applications, deoxycholic acid is used in treatments to break down and absorb fat cells, such as in the injectable treatment Kybella for reducing submental fat (double chin).

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research Deoxycholic Acid in Submental Fat Reduction: A Review of Properties, Adverse Effects, and Complications

25 citations, July 2020 in “Journal of cosmetic dermatology”

Deoxycholic acid is effective for reducing chin fat but can cause side effects and serious complications, so careful patient evaluation is needed.

research Alopecia Following Deoxycholic Acid Treatment for Submental Adiposity

17 citations, August 2019 in “JAMA Facial Plastic Surgery”

Some men lost hair after deoxycholic acid treatment for neck fat, but most saw improvement or resolution.

research Assessing the Efficacy of Deoxycholic Acid for the Treatment of Submental Fat: A Three-Dimensional Study

7 citations, September 2018 in “Aesthetic surgery journal”

Deoxycholic acid effectively reduces double chin fat with temporary side effects and high patient satisfaction.

Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

research Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

January 2023 in “Bioorganičeskaâ himiâ”

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

research Lipolytic Agents for Submental Fat Reduction: Review

1 citations, January 2024 in “Skin research and technology”

Deoxycholic acid is FDA-approved for reducing submental fat, but its mechanisms are not fully understood.

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