Eph Receptors and Ephrins: Therapeutic Opportunities
October 2014
in “
Annual Review of Pharmacology and Toxicology
”
TLDR Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.
The 2015 review article explores the potential of Eph receptors and ephrins as therapeutic targets for a variety of diseases, including neurological disorders, cancer, and viral infections. It discusses the role of these molecules in disease pathology and the development of strategies to modulate their expression and function. The review highlights the complexity of the Eph receptor/ephrin system and the need for a thorough understanding of their involvement in diseases to develop effective therapies. It also outlines various strategies for modulating Eph receptor and ephrin activities, including the use of recombinant proteins, antibodies, peptides, small molecules, and nucleic acid-based agents. Despite promising preclinical data, the review notes limited clinical data and the importance of selectivity and understanding of signaling mechanisms to minimize toxicity. The document also mentions ongoing clinical trials and the potential for personalized treatments based on Eph/ephrin expression in tumors.
