Anti-Aging Potential of Gypenosides Fraction Obtained from Naturally Grown Gynostemma Pentaphyllum in Ulleungdo Island and Its Seven New Gypenosides

The study from May 2016 explored the anti-aging effects of gypenosides fraction (GFGP) from Gynostemma pentaphyllum, discovering seven new gypenosides (UL1-UL7). In vitro, GFGP enhanced procollagen type-1 production in human dermal fibroblasts by up to 43% at 20 µg/g, outperforming N-acetylglucosamine (NAG). An in vivo study with 24 female participants over 8 weeks showed that a cream containing GFGP reduced periorbital wrinkles by about 14% compared to a non-treated group, with significant improvements over a control vehicle. Two of the new gypenosides, UL4 and UL5, were confirmed to boost procollagen synthesis and demonstrated high thermal stability in cosmetic formulations, retaining over 90% of their content after 12 weeks without changes in appearance or smell.