Gynostemma Pentaphyllum Hydrodistillate and Damulin B Prevent UVB-Induced Photoaging In Vitro and In Vivo via ROS Suppression and Restoration of MAPK/AP-1 and TGF-β/Smad Signaling

January 2026 in “ Molecular Nutrition & Food Research ”

SeoYeon Lee, Lochana Kovale, Jihyun Lee … Joohun Ha

Gynostemma pentaphyllum Damulin B UVB-induced skin damage reactive oxygen species MAPK/AP-1 signaling TGF-β/Smad signaling extracellular matrix hyaluronic acid metabolism collagen degradation epidermal hyperplasia GPHD ROS ECM

Studysummary This study found that Gynostemma pentaphyllum hydrodistillate and Damulin B exert significant anti-photoaging effects in UVB-irradiated models by reducing oxidative stress, improving ECM integrity, and enhancing skin hydration and elasticity.

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