Gynostemma Pentaphyllum Hydrodistillate and Its Major Component Damulin B Promote Hair Growth via the Wnt/Beta-Catenin Pathway

    March 2024 in “ Nutrients
    Lochana Kovale, Seo Yeon Lee, Minhyeok Song, Ji‐Hyun Lee, Hyeong Jig Son, Young Kwan Sung, Mi Hee Kwack, Wonchae Choe, Insug Kang, Sung Soo Kim, Joohun Ha
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    TLDR Gynostemma pentaphyllum and its component damulin B could help hair grow by activating certain cell pathways.
    The study investigated the hair growth properties of Gynostemma pentaphyllum leaf hydrodistillate (GPHD) and its major component, damulin B, in both in vitro and in vivo settings. The research found that GPHD and damulin B promoted hair growth in mice and increased the proliferation of human dermal papilla cells (hDPCs), similar to the effects of minoxidil, a common hair growth treatment. The mechanism of action was found to be through the activation of the Wnt/β-catenin pathway via the AKT/GSK3β pathway. The study involved three groups of five mice each, with one group receiving GPHD, another receiving minoxidil, and a control group. The GPHD group showed significant hair growth compared to the control group. The study concludes that GPHD and damulin B could potentially be used as treatments for promoting hair growth.
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