Effects of a New Recombinant Human Collagen on Skin Aging

    April 2023 in “ Journal of Investigative Dermatology ”
    L. Shi, J. Zhao, G. Xu, W. Liu, M. Chen
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    TLDR The new recombinant human collagen can help slow skin aging and repair skin, while also controlling inflammation.
    The study conducted by the Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, investigated the potential application of a new recombinant human collagen in improving skin aging and modulating inflammatory responses. The recombinant type III collagen was found to significantly promote the proliferation and migration of fibroblasts, suggesting its potential anti-aging and repairing effect. Its proliferation-promoting effect was 40% of that of Retinol, and its repair effect can reach 50% of fibronectin. While the collagen had no significant effect on inhibiting the secretion of TNF-α, it was significantly better than dexamethasone at inhibiting IL-6. These findings highlight the potential use of recombinant type III collagen as a bioactive agent to regulate the skin aging process through anti-aging, repairing, and modulating inflammation.
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