Atelocollagen Increases Collagen Synthesis by Promoting Glycine Transporter 1 in Aged Mouse Skin

This study explores the impact of atelocollagen on collagen synthesis in aged skin, highlighting its role in enhancing glycine uptake through GlyT1. Treatment with atelocollagen in human dermal fibroblasts and aged mouse skin led to increased GlyT1 expression, higher intracellular glycine levels, and reduced oxidative stress. These effects resulted in decreased NF-κB activity, lower matrix metalloproteinase expression, increased SMAD2/3 phosphorylation, and upregulated type I/III collagen synthesis. Histological analysis showed improved collagen density and skin elasticity in treated mice. The study suggests that atelocollagen could be a potential strategy for skin rejuvenation by enhancing collagen synthesis and reducing oxidative stress through GlyT1-dependent glycine transport. Further research is needed to understand the long-term effects and safety.