Effects of Collagen Type XVII Alpha 1 on Epidermal Stem Cells in Aging Skin and the MicroRNA Intervention Mechanism

    September 2022 in “ PubMed ”
    Jiachen Sun, Ting Sun, Z A Shen, H Q Zhao, X Z Liu, Y J Zhang
    TLDR Collagen type XVII α1 decreases with age, leading to skin aging, but targeting microRNA-203b-3p may help maintain its levels and improve skin health.
    The study "[Effects of collagen type ⅩⅦ α1 on epidermal stem cells in aging skin and the microRNA intervention mechanism]" investigates the role of collagen type ⅩⅦ α1 in the aging process of skin and its impact on epidermal stem cells. The research found that collagen type ⅩⅦ α1 has a significant effect on the vitality and function of these stem cells, which are crucial for skin regeneration and hair growth. As skin ages, the expression of this collagen decreases, leading to a reduction in the functionality of the stem cells. The study also explored the potential of microRNA as a mechanism to intervene in this process, suggesting that it could be used to regulate the expression of collagen type ⅩⅦ α1 and potentially slow down skin aging and hair loss.
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