TLDR The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.
The study demonstrated that the Vitamin D Receptor (VDR) played a crucial role in skin homeostasis, hair follicle cycling, and protection against UV-induced skin carcinogenesis, independent of its ligand, 1,25-dihydroxyvitamin D3. VDR knockout mice exhibited hair follicle cycling defects, skin abnormalities, and 100% tumor development with chronic UVB exposure, unlike wild-type controls. VDR was essential for UV-induced cell cycle arrest, DNA repair, and apoptosis, and could control gene expression in keratinocytes without its traditional ligand. These findings suggested potential therapeutic targets for treating skin disorders and hair loss conditions.
148 citations,
October 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Mice without the vitamin D receptor are more prone to UV-induced skin tumors.
271 citations,
September 2008 in “Nutrition reviews” Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.
36 citations,
February 2007 in “Journal of biological chemistry/The Journal of biological chemistry” The vitamin D receptor can work without its usual activating molecule.
81 citations,
January 2006 in “Journal of cellular physiology” Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.
78 citations,
November 2005 in “Endocrinology” Hairless protein can block vitamin D activation in skin cells.
276 citations,
April 2003 in “Molecular endocrinology” Vitamin D is important for bones, hair, blood pressure, and breast development.
180 citations,
January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Vitamin D Receptor is crucial for normal skin and hair growth.
18 citations,
July 2010 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.
78 citations,
November 2005 in “Endocrinology” Hairless protein can block vitamin D activation in skin cells.
