The 1,25-Dihydroxyvitamin D3-Independent Actions of the Vitamin D Receptor in Skin

    April 2010 in “ Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology ”
    Diane R. Dowd, Paul N. MacDonald
    Studysummary This research suggests that the vitamin D receptor may regulate hair follicle cycling and provide genoprotection against skin carcinogenesis through a mechanism independent of 1,25-dihydroxyvitamin D3, based on evidence from mouse models.
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    Research cited in this study 15

    1. Vitamin D Receptor: Molecular Signaling and Actions of Nutritional Ligands in Disease Prevention Nutrition reviews · 2008
    2. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    3. Evidence for 1,25-Dihydroxyvitamin D3-Independent Transactivation by the Vitamin D Receptor Journal of biological chemistry/˜The œJournal of biological chemistry · 2007
    4. Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse Journal of cellular physiology · 2006
    5. Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology · 2005
    6. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004
    7. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    8. Vitamin D: More Than a Bona Fide Hormone Molecular endocrinology · 2003
    9. Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    10. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001
    11. The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor Genes & Development · 2001
    12. Metabolic And Cellular Analysis Of Alopecia In Vitamin D Receptor Knockout Mice Journal of Clinical Investigation · 2001
    13. Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice Endocrinology · 2000
    14. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice Endocrinology · 1998
    15. Alopecia Universalis Associated With a Mutation in the Human Hairless Gene Science · 1998

    Related research 2

    1. The 1,25-Dihydroxyvitamin D3-Independent Actions of the Vitamin D Receptor in Skin Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2010
    2. Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology · 2005