Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis

    May 2008 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Tara I. Ellison, Michael L. Smith, Anita C. Gilliam, Paul N. MacDonald
    TLDR Mice without the vitamin D receptor are more prone to UV-induced skin tumors.
    The study concluded that inactivation of the Vitamin D Receptor (VDR) in mice increased their susceptibility to UV-induced skin tumorigenesis. VDR−/− mice developed skin tumors more rapidly and frequently than wildtype controls, showing compromised DNA repair, defective UV-induced growth arrest and apoptosis, and reduced epidermal thickening in response to UV exposure. These findings highlighted the critical protective role of VDR in preventing UV-induced skin damage and tumor formation, independent of its ligand, 1,25(OH)2D3. The study involved various groups of mice with sample sizes ranging from 6 to 23 per group.
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