Cell Death in the Skin: Mechanisms and Implications

The document from 2009 explores the mechanisms of cell death in the skin, with a particular focus on apoptosis and its implications for skin health and disease. It describes how apoptosis is essential for skin homeostasis, with processes like cornification in keratinocytes and cyclic apoptosis in hair follicles being crucial for normal skin and hair function. NF-kB is highlighted as a key protector against apoptosis, especially under inflammatory conditions, and its dysregulation can lead to skin diseases, including cancer. The paper also discusses the impact of UV radiation on skin cells, causing DNA damage and apoptosis, with the p53 protein playing a significant role in mediating the skin's response to UV damage. Additionally, the document touches on the potential of targeting apoptotic pathways for cancer therapy and the role of apoptosis in severe skin reactions and autoimmune diseases. It emphasizes the importance of understanding these cell death mechanisms for developing new treatments for skin conditions and preventing hair loss.