702 dsRNA Induces Ectopic KRT9 Expression via WNT/β-Catenin-Mediated Signaling

The document from May 2016 reported on various studies related to hair growth and alopecia. One study demonstrated that Prostaglandin D₂ (PGD₂) inhibits hair growth, but its effects can be reversed by antagonists of the PGD₂ receptor PTGDR2, offering a potential alopecia treatment. Another study found that lithocholic acid (LCA) promotes hair growth by activating the vitamin D receptor, suggesting its importance in hair regeneration. A third study revealed that oncostatin M helps maintain hair follicle stem cells' quiescence during the hair cycle's resting phase, which is crucial for hair growth regulation. Specifically, the study "702 dsRNA induces ectopic KRT9 expression via WNT/β-catenin-mediated signaling" showed that double-stranded RNA (dsRNA) activates WNT/β-catenin signaling to induce KRT9 expression, a characteristic of volar skin, indicating a role in the adaptation of palms and soles to mechanical stress. Additional studies discussed the development of hair follicles and the anti-aging effects of gypenosides. The number of participants in these studies was not provided.