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    Glossary Double-stranded RNA

    molecule with two complementary RNA strands bound together

    Double-stranded RNA (dsRNA) is a molecule consisting of two complementary strands of RNA that are bound together, similar to the structure of DNA. In biological systems, dsRNA is often a signal of viral infection, triggering immune responses in cells. It is also used in research and therapeutic applications, such as RNA interference (RNAi), to silence specific genes.

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    1. Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles Scientific reports · 2017 · 22 citations
    2. 1410 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration 2018
    3. 944 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration Journal of Investigative Dermatology · 2019
    4. Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding Seminars in Cell & Developmental Biology · 2019 · 28 citations
    5. Hypothesis: Wound‐induced TLR3 activation stimulates endogenous retinoic acid synthesis and signalling during regeneration Experimental dermatology · 2019 · 5 citations
    6. 1452 Noncoding dsRNA stimulates exosome biosynthesis to regulate skin regeneration 2023
    7. 850 After skin wounding, noncoding dsRNA coordinates prostaglandins and WNT7b to promote regeneration 2017
    8. 702 dsRNA induces ectopic KRT9 expression via WNT/β-catenin-mediated signaling Journal of Investigative Dermatology · 2016
    9. Abstract 152 Plastic and Reconstructive Surgery · 2015
    10. 766 H3K9me3 methyltransferase SETDB1 controls retrotransposon silencing, DNA methylation, constitutive heterochromatin maintenance and 3D-chromatin structure in epidermal keratinocytes 2023
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