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Glossary Anti-double-stranded DNA antibody

autoantibodies targeting DNA, linked to autoimmune diseases

Anti-double-stranded DNA (anti-dsDNA) antibodies are autoantibodies that specifically target the double-stranded form of DNA, often associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE). Their relevance to hair loss lies in the fact that autoimmune conditions can lead to hair loss through mechanisms such as inflammation and follicle damage. Key distinguishing characteristics of anti-dsDNA antibodies include their high specificity for SLE and their correlation with disease activity, making them important markers in both diagnosis and monitoring of the disease.

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A Rare Case of Antinuclear Antibody-Negative Systemic Lupus Erythematosus Presenting With Generalized Lymphadenopathy as the Initial Manifestation

research A Rare Case of Antinuclear Antibody-Negative Systemic Lupus Erythematosus Presenting With Generalized Lymphadenopathy as the Initial Manifestation

October 2025 in “Cureus”

This case report highlights the diagnostic challenge of ANA-negative pediatric SLE in South Asia, emphasizing the need for comprehensive diagnostic criteria and clinical vigilance for early recognition and treatment.

research A Case of Rhupus with Rowell Syndrome

3 citations , June 2020 in “Open access rheumatology”

This case report reviews the management of Rowell syndrome in a patient initially diagnosed with Rhupus syndrome and highlights their development of erythema multiforme after certain medications.

research Tuberculosis mimicking the onset of systemic lupus erythematosus flare: Case based review

1 citations , February 2023 in “International Journal of Rheumatic Diseases”

This study reported that tuberculosis can mimic lupus-like symptoms, including the production of autoantibodies, which may confuse the diagnosis with systemic lupus erythematosus flares.

research Abstract 10845: Spontaneous Coronary Artery Dissection as the Primary Presentation of Ana-Negative Lupus

November 2021 in “Circulation”

This case report highlights the first known instance of ANA-negative systemic lupus erythematosus presenting as spontaneous coronary artery dissection, emphasizing a need for rheumatological evaluation in such patients.

research A Case of Rhupus with Rowell Syndrome

4 citations , June 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)”

This case report describes a 30-year-old woman diagnosed with both Rhupus and Rowell syndromes, and details her presentation and treatment plan, without reporting specific treatment outcomes.

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