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    Glossary Double-stranded RNA

    molecule with two complementary RNA strands bound together

    Double-stranded RNA (dsRNA) is a molecule consisting of two complementary strands of RNA that are bound together, similar to the structure of DNA. In biological systems, dsRNA is often a signal of viral infection, triggering immune responses in cells. It is also used in research and therapeutic applications, such as RNA interference (RNAi), to silence specific genes.

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    1. Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles Scientific reports · 2017 · 22 citations
    2. 1410 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration 2018
    3. 944 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration Journal of Investigative Dermatology · 2019
    4. Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding Seminars in Cell & Developmental Biology · 2019 · 28 citations
    5. Hypothesis: Wound‐induced TLR3 activation stimulates endogenous retinoic acid synthesis and signalling during regeneration Experimental dermatology · 2019 · 5 citations
    6. 1452 Noncoding dsRNA stimulates exosome biosynthesis to regulate skin regeneration 2023
    7. 850 After skin wounding, noncoding dsRNA coordinates prostaglandins and WNT7b to promote regeneration 2017
    8. 702 dsRNA induces ectopic KRT9 expression via WNT/β-catenin-mediated signaling Journal of Investigative Dermatology · 2016
    9. Abstract 152 Plastic and Reconstructive Surgery · 2015
    10. 766 H3K9me3 methyltransferase SETDB1 controls retrotransposon silencing, DNA methylation, constitutive heterochromatin maintenance and 3D-chromatin structure in epidermal keratinocytes 2023
    11. The pattern recognition receptor toll-like receptor 3 regulates skin barrier homeostasis eScholarship (California Digital Library) · 2014
    12. After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration Journal of Investigative Dermatology · 2017 · 27 citations
    13. A Perspective on RNAi-Based Biopesticides Frontiers in Plant Science · 2020 · 140 citations
    14. Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit (Oryctolagus cuniculus) Hair Follicle Cycle by RNA Sequencing Frontiers in genetics · 2019 · 35 citations
    15. Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. Molecular Endocrinology · 1994 · 24 citations
    16. Keratinocyte Growth Factor Modified Messenger RNA Accelerating Cell Proliferation and Migration of Keratinocytes Nucleic Acid Therapeutics · 2018 · 11 citations
    17. Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner Cell Death & Differentiation · 2016 · 42 citations
    18. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds Nature Communications · 2019 · 301 citations
    19. Stem cell dynamics, migration and plasticity during wound healing Nature Cell Biology · 2018 · 211 citations
    20. Keratin disorders: from gene to therapy 2011 · 109 citations
    21. A symphony of signals: the intricate role of lncRNAs in dermatological disorders Clinical and Experimental Medicine · 2025 · 1 citations
    22. MicroRNA-mediated regulation of hair follicle regeneration: mechanisms, delivery strategies, and translational perspectives Frontiers in Cell and Developmental Biology · 2026
    23. Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases 2026
    24. Identifying molecular targets for reverse aging using integrated network analysis of transcriptomic and epigenomic changes during aging Scientific Reports · 2021 · 12 citations
    25. Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study Clinical, Cosmetic and Investigational Dermatology · 2019 · 7 citations
    26. The PDGF/PDGFR pathway as a drug target Molecular Aspects of Medicine · 2017 · 182 citations
    27. Wound healing mechanism in Mongolian gerbil skin Histochemistry and Cell Biology · 2018 · 6 citations
    28. Self-Amplifying RNA Approach for Protein Replacement Therapy International Journal of Molecular Sciences · 2022 · 8 citations
    29. Integrated analysis of coding genes and non-coding RNAs during hair follicle cycle of cashmere goat (Capra hircus) BMC Genomics · 2017 · 129 citations
    30. The Molecular Revolution in Cutaneous Biology: Noncoding RNAs: New Molecular Players in Dermatology and Cutaneous Biology Journal of Investigative Dermatology · 2017 · 22 citations